6im6: Difference between revisions

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-'''Unreleased structure'''
-The entry 6im6 is ON HOLD
+==Crystal structure of PDE4D complexed with a novel inhibitor==
+<StructureSection load='6im6' size='340' side='right'caption='[[6im6]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6im6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IM6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IM6 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.702&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AH3:7-ethoxy-6-methoxy-3,4-dihydroisoquinoline-2(1H)-carbaldehyde'>AH3</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6im6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6im6 OCA], [https://pdbe.org/6im6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6im6 RCSB], [https://www.ebi.ac.uk/pdbsum/6im6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6im6 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/PDE4D_HUMAN PDE4D_HUMAN] Note=Genetic variations in PDE4D might be associated with susceptibility to stroke. PubMed:17006457 states that association with stroke has to be considered with caution.  Defects in PDE4D are the cause of acrodysostosis type 2, with or without hormone resistance (ACRDYS2) [MIM:[https://omim.org/entry/614613 614613]. ACRDYS2 is a pleiotropic disorder characterized by skeletal, endocrine, and neurological abnormalities. Skeletal features include brachycephaly, midface hypoplasia with a small upturned nose, brachydactyly, and lumbar spinal stenosis. Endocrine abnormalities include hypothyroidism and hypogonadism in males and irregular menses in females. Developmental disability is a common finding but is variable in severity and can be associated with significant behavioral problems.<ref>PMID:22464250</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/PDE4D_HUMAN PDE4D_HUMAN] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.<ref>PMID:15260978</ref> <ref>PMID:15576036</ref>
-Authors: Zhang, X.L., Su, H.X., Xu, Y.C.
+==See Also==
+*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
-Description: Crystal structure of PDE4D complexed with a novel inhibitor
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Su, H.X]]
+__TOC__
-[[Category: Zhang, X.L]]
+</StructureSection>
-[[Category: Xu, Y.C]]
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Su HX]]
+[[Category: Xu YC]]
+[[Category: Zhang XL]]