6afr: Difference between revisions

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-'''Unreleased structure'''
-The entry 6afr is ON HOLD  until Paper Publication
+==Crystal Structure of the first bromodomain of human BRD4 in complex with 5-((4-fluoro-1H-imidazol-1-yl)methyl)quinolin-8-ol==
+<StructureSection load='6afr' size='340' side='right'caption='[[6afr]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6afr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AFR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AFR FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.998&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9E3:5-[(4-fluoranylimidazol-1-yl)methyl]quinolin-8-ol'>9E3</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6afr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6afr OCA], [https://pdbe.org/6afr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6afr RCSB], [https://www.ebi.ac.uk/pdbsum/6afr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6afr ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
-Authors: Xing, J., Zhang, R.K., Zheng, M.Y., Luo, C., Jiang, X.R.
+==See Also==
+*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
-Description: Crystal Structure of the first bromodomain of human BRD4 in complex with 5-((4-fluoro-1H-imidazol-1-yl)methyl)quinolin-8-ol
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Zheng, M.Y]]
+__TOC__
-[[Category: Zhang, R.K]]
+</StructureSection>
-[[Category: Luo, C]]
+[[Category: Homo sapiens]]
-[[Category: Jiang, X.R]]
+[[Category: Large Structures]]
-[[Category: Xing, J]]
+[[Category: Jiang XR]]
+[[Category: Luo C]]
+[[Category: Xing J]]
+[[Category: Zhang RK]]
+[[Category: Zheng MY]]