5zzd: Difference between revisions

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-'''Unreleased structure'''
-The entry 5zzd is ON HOLD
+==Crystal structure of a protein from Aspergillus flavus==
+<StructureSection load='5zzd' size='340' side='right'caption='[[5zzd]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
-Authors: Chang, Z.Y., Liu, W.D., Chen, C.C., Guo, R.T.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5zzd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_flavus_NRRL3357 Aspergillus flavus NRRL3357]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZZD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZZD FirstGlance]. <br>
-Description: Crystal structure of a protein from Aspergillus flavus
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
-[[Category: Chang, Z.Y]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zzd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zzd OCA], [https://pdbe.org/5zzd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zzd RCSB], [https://www.ebi.ac.uk/pdbsum/5zzd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zzd ProSAT]</span></td></tr>
-[[Category: Liu, W.D]]
+</table>
-[[Category: Chen, C.C]]
+== Function ==
-[[Category: Guo, R.T]]
+[https://www.uniprot.org/uniprot/LEPI_ASPFN LEPI_ASPFN] O-methyltransferase; part of the gene cluster 23 that mediates the biosynthesis of a family of 2-pyridones known as leporins (PubMed:20447271, PubMed:26051490). The hybrid PKS-NRPS synthetase lepA and the enoyl reductase lepG are responsible for fusion of phenylalanine with a hexaketide and subsequent release of the stable tetramic acid precursor, pre-leporin C (PubMed:26051490). Because lepA lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase lepG (PubMed:26051490). It is possible that the dehydrogenase lepF also participates in production of pre-leporin C (PubMed:26051490). Cytochrome P450 monooxygenase lepH is then required for the ring expansion step to yield leporin C (PubMed:26051490). Leporin C is then presumably further oxidized by the N-hydroxylase lepD to form leporin B (PubMed:26051490). LepI may possess a function in biosynthesis upstream of lepA (PubMed:26051490). Leporin B is further oxidized in the presence of ferric ion to give the leporin B trimer-iron chelate, but whether or not this reaction is catalyzed by an enzyme in the pathway or by ferric ion is not determined yet (PubMed:26051490).<ref>PMID:26051490</ref> <ref>PMID:20447271</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Aspergillus flavus NRRL3357]]
+[[Category: Large Structures]]
+[[Category: Chang ZY]]
+[[Category: Chen CC]]
+[[Category: Guo RT]]
+[[Category: Liu WD]]