5ysm: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
No edit summary
No edit summary
 
(One intermediate revision by the same user not shown)
Line 1: Line 1:


==Crystal Structure Analysis of Rif16==
==Crystal Structure Analysis of Rif16==
<StructureSection load='5ysm' size='340' side='right' caption='[[5ysm]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='5ysm' size='340' side='right'caption='[[5ysm]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5ysm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YSM FirstGlance]. <br>
<table><tr><td colspan='2'>[[5ysm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Amycolatopsis_mediterranei_U32 Amycolatopsis mediterranei U32]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YSM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YSM FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ysm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ysm OCA], [http://pdbe.org/5ysm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ysm RCSB], [http://www.ebi.ac.uk/pdbsum/5ysm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ysm ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ysm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ysm OCA], [https://pdbe.org/5ysm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ysm RCSB], [https://www.ebi.ac.uk/pdbsum/5ysm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ysm ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/A0A0H3CVZ6_AMYMU A0A0H3CVZ6_AMYMU]
Rifamycin-derived drugs, including rifampin, rifabutin, rifapentine, and rifaximin, have long been used as first-line therapies for the treatment of tuberculosis and other deadly infections. However, the late steps leading to the biosynthesis of the industrially important rifamycin SV and B remain largely unknown. Here, we characterize a network of reactions underlying the biosynthesis of rifamycin SV, S, L, O, and B. The two-subunit transketolase Rif15 and the cytochrome P450 enzyme Rif16 are found to mediate, respectively, a unique C-O bond formation in rifamycin L and an atypical P450 ester-to-ether transformation from rifamycin L to B. Both reactions showcase interesting chemistries for these two widespread and well-studied enzyme families.


Deciphering the late steps of rifamycin biosynthesis.,Qi F, Lei C, Li F, Zhang X, Wang J, Zhang W, Fan Z, Li W, Tang GL, Xiao Y, Zhao G, Li S Nat Commun. 2018 Jun 14;9(1):2342. doi: 10.1038/s41467-018-04772-x. PMID:29904078<ref>PMID:29904078</ref>
==See Also==
 
*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5ysm" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Li, F W]]
[[Category: Amycolatopsis mediterranei U32]]
[[Category: Li, S Y]]
[[Category: Large Structures]]
[[Category: Qi, F F]]
[[Category: Li FW]]
[[Category: Xiao, Y L]]
[[Category: Li SY]]
[[Category: Zhao, G P]]
[[Category: Qi FF]]
[[Category: Cytochrome p450]]
[[Category: Xiao YL]]
[[Category: Metal binding protein]]
[[Category: Zhao GP]]
[[Category: Oxidoreductase]]
[[Category: Rifamycin]]

Latest revision as of 13:24, 27 March 2024

Crystal Structure Analysis of Rif16Crystal Structure Analysis of Rif16

Structural highlights

5ysm is a 1 chain structure with sequence from Amycolatopsis mediterranei U32. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

A0A0H3CVZ6_AMYMU

See Also

5ysm, resolution 1.90Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=5ysm&oldid=4111779"