5ynv: Difference between revisions

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-==Crystal structure of an aromatic prenyltransferase in complex with ligand2==
+==Crystal structure of an aromatic prenyltransferase FAMD1 from Fischerella ambigua UTEX 1903 in complex with DMASPP==
-<StructureSection load='5ynv' size='340' side='right' caption='[[5ynv]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
+<StructureSection load='5ynv' size='340' side='right'caption='[[5ynv]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5ynv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YNV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YNV FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5ynv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Fischerella_ambigua_UTEX_1903 Fischerella ambigua UTEX 1903]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YNV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YNV FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DST:DIMETHYLALLYL+S-THIOLODIPHOSPHATE'>DST</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ynt|5ynt]], [[5ynu|5ynu]], [[5ynw|5ynw]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DST:DIMETHYLALLYL+S-THIOLODIPHOSPHATE'>DST</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ynv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ynv OCA], [http://pdbe.org/5ynv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ynv RCSB], [http://www.ebi.ac.uk/pdbsum/5ynv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ynv ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ynv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ynv OCA], [https://pdbe.org/5ynv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ynv RCSB], [https://www.ebi.ac.uk/pdbsum/5ynv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ynv ProSAT]</span></td></tr>
 </table>
-<div style="background-color:#fffaf0;">
+== Function ==
-== Publication Abstract from PubMed ==
+[https://www.uniprot.org/uniprot/V5TDY7_FISAU V5TDY7_FISAU]
-FamD1 is a novel CloQ/NphB-family indole prenyltransferase which involves in hapalindole-type alkaloid biosynthesis. Here the native FamD1 structure and three protein-ligand complexes are analyzed to investigate the molecular basis of substrate binding and catalysis. FamD1 adopts a typical ABBA architecture of aromatic prenyltransferase, in which the substrate-binding chamber is found in the central beta-barrel. The indole-containing acceptor substrate is bound adjacent to the prenyl donor. Based on the complex structures, a catalytic mechanism of FamD1 is proposed. Functional implications on the sister enzyme FamD2 are also discussed.
-Structural insight into a novel indole prenyltransferase in hapalindole-type alkaloid biosynthesis.,Wang J, Chen CC, Yang Y, Liu W, Ko TP, Shang N, Hu X, Xie Y, Huang JW, Zhang Y, Guo RT Biochem Biophys Res Commun. 2018 Jan 8;495(2):1782-1788. doi:, 10.1016/j.bbrc.2017.12.039. Epub 2017 Dec 8. PMID:29229390<ref>PMID:29229390</ref>
-From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-</div>
-<div class="pdbe-citations 5ynv" style="background-color:#fffaf0;"></div>
-== References ==
-<references/>
 __TOC__
 </StructureSection>
-[[Category: Chen, C C]]
+[[Category: Fischerella ambigua UTEX 1903]]
-[[Category: Guo, R T]]
+[[Category: Large Structures]]
-[[Category: Liu, W D]]
+[[Category: Chen CC]]
-[[Category: Wang, J]]
+[[Category: Guo RT]]
-[[Category: Prenyltransferase]]
+[[Category: Liu WD]]
-[[Category: Transferase]]
+[[Category: Wang J]]