5ygi: Difference between revisions

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 ==Crystal structure of human FPPS in complex with an inhibitor THZ93==
-<StructureSection load='5ygi' size='340' side='right' caption='[[5ygi]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
+<StructureSection load='5ygi' size='340' side='right'caption='[[5ygi]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5ygi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YGI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YGI FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5ygi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YGI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YGI FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=T93:[[(4-hexoxypyridin-2-yl)amino]-phosphono-methyl]phosphonic+acid'>T93</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.177&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ygi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ygi OCA], [http://pdbe.org/5ygi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ygi RCSB], [http://www.ebi.ac.uk/pdbsum/5ygi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ygi ProSAT]</span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=T93:[[(4-hexoxypyridin-2-yl)amino]-phosphono-methyl]phosphonic+acid'>T93</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ygi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ygi OCA], [https://pdbe.org/5ygi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ygi RCSB], [https://www.ebi.ac.uk/pdbsum/5ygi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ygi ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
+[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
+==See Also==
+*[[Farnesyl diphosphate synthase 3D structures|Farnesyl diphosphate synthase 3D structures]]
 __TOC__
 </StructureSection>
-[[Category: Li, X]]
+[[Category: Homo sapiens]]
-[[Category: Complex]]
+[[Category: Large Structures]]
-[[Category: Human fpp]]
+[[Category: Li X]]
-[[Category: Thz93]]
-[[Category: Transferase-transferase inhibitor complex]]