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==Cytoplasmic dynein-A heavy chain bound to dynactin-p150glued and IC-LC tower== | |||
<StructureSection load='8pr0' size='340' side='right'caption='[[8pr0]], [[Resolution|resolution]] 9.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8pr0]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PR0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PR0 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 9.4Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pr0 OCA], [https://pdbe.org/8pr0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pr0 RCSB], [https://www.ebi.ac.uk/pdbsum/8pr0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pr0 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DC1I2_HUMAN DC1I2_HUMAN] Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Sus scrofa]] | |||
[[Category: Carter AP]] | |||
[[Category: Gassmann R]] | |||
[[Category: Lau CK]] | |||
[[Category: Manigrasso G]] | |||
[[Category: Singh K]] | |||
Latest revision as of 13:11, 27 March 2024
Cytoplasmic dynein-A heavy chain bound to dynactin-p150glued and IC-LC towerCytoplasmic dynein-A heavy chain bound to dynactin-p150glued and IC-LC tower
Structural highlights
FunctionDC1I2_HUMAN Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes. |
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