How B-lactam drugs work: Difference between revisions
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How do bacteria become resistant to penicillin and other beta lactam antibiotics? Some bacteria have an enzyme called penicillinase, which inactivates penicillin by cutting the beta lactam ring to form a carboxylic acid and an amine. This prevents the antibiotic from reacting with the serine residue in the transpeptidase, making it inactive. The gene for this enzyme is located on a bacterial plasmid, and can be transferred from one bacteria to another, causing antibacterial resistance to spread. | How do bacteria become resistant to penicillin and other beta lactam antibiotics? Some bacteria have an enzyme called penicillinase, which inactivates penicillin by cutting the beta lactam ring to form a carboxylic acid and an amine. This prevents the antibiotic from reacting with the serine residue in the transpeptidase, making it inactive. The gene for this enzyme is located on a bacterial plasmid, and can be transferred from one bacteria to another, causing antibacterial resistance to spread. | ||
For more information about penicillin binding proteins, please see the Molecule of the Month page for penicillin binding proteins. [https://pdb101.rcsb.org/motm/29] | For more information about penicillin binding proteins, please see the Molecule of the Month page for penicillin binding proteins. [https://pdb101.rcsb.org/motm/29] and [[Penicillin-binding protein]]. | ||
See also [[Beta-lactam antibiotics]] | |||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
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