1fc4: Difference between revisions

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[[Image:1fc4.png|left|200px]]


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==2-AMINO-3-KETOBUTYRATE COA LIGASE==
The line below this paragraph, containing "STRUCTURE_1fc4", creates the "Structure Box" on the page.
<StructureSection load='1fc4' size='340' side='right'caption='[[1fc4]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1fc4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FC4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FC4 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKB:2-AMINO-3-KETOBUTYRIC+ACID'>AKB</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
{{STRUCTURE_1fc4|  PDB=1fc4  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fc4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fc4 OCA], [https://pdbe.org/1fc4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fc4 RCSB], [https://www.ebi.ac.uk/pdbsum/1fc4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fc4 ProSAT], [https://www.topsan.org/Proteins/BSGI/1fc4 TOPSAN]</span></td></tr>
 
</table>
===2-AMINO-3-KETOBUTYRATE COA LIGASE===
== Function ==
 
[https://www.uniprot.org/uniprot/KBL_ECOLI KBL_ECOLI] Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.<ref>PMID:2104756</ref>
 
== Evolutionary Conservation ==
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==About this Structure==
  </jmolCheckbox>
1FC4 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FC4 OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fc4 ConSurf].
 
<div style="clear:both"></div>
==Reference==
== References ==
Three-dimensional structure of 2-amino-3-ketobutyrate CoA ligase from Escherichia coli complexed with a PLP-substrate intermediate: inferred reaction mechanism., Schmidt A, Sivaraman J, Li Y, Larocque R, Barbosa JA, Smith C, Matte A, Schrag JD, Cygler M, Biochemistry. 2001 May 1;40(17):5151-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11318637 11318637]
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Glycine C-acetyltransferase]]
[[Category: Large Structures]]
[[Category: BSGI, Montreal-Kingston Bacterial Structural Genomics Initiative.]]
[[Category: Cygler M]]
[[Category: Cygler, M.]]
[[Category: Larocque R]]
[[Category: Larocque, R.]]
[[Category: Li Y]]
[[Category: Li, Y.]]
[[Category: Matte A]]
[[Category: Matte, A.]]
[[Category: Sauve V]]
[[Category: Sauve, V.]]
[[Category: Schmidt A]]
[[Category: Schmidt, A.]]
[[Category: Schrag JD]]
[[Category: Schrag, J D.]]
[[Category: Sivaraman J]]
[[Category: Sivaraman, J.]]
[[Category: Smith C]]
[[Category: Smith, C.]]
[[Category: 2-amino-3-ketobutyrate coa ligase]]
[[Category: Bsgi]]
[[Category: Coenzyme some]]
[[Category: Montreal-kingston bacterial structural genomics initiative]]
[[Category: Pyridoxal phosphate]]
[[Category: Structural genomic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 12:07:34 2008''

Latest revision as of 13:13, 20 March 2024

2-AMINO-3-KETOBUTYRATE COA LIGASE2-AMINO-3-KETOBUTYRATE COA LIGASE

Structural highlights

1fc4 is a 2 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

KBL_ECOLI Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Mukherjee JJ, Dekker EE. 2-Amino-3-ketobutyrate CoA ligase of Escherichia coli: stoichiometry of pyridoxal phosphate binding and location of the pyridoxyllysine peptide in the primary structure of the enzyme. Biochim Biophys Acta. 1990 Jan 19;1037(1):24-9. PMID:2104756

1fc4, resolution 2.00Å

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