1fbr: Difference between revisions

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-{{Seed}}
-[[Image:1fbr.png|left|200px]]
-<!--
+==FOURTH AND FIFTH FIBRONECTIN TYPE I MODULE PAIR==
-The line below this paragraph, containing "STRUCTURE_1fbr", creates the "Structure Box" on the page.
+<StructureSection load='1fbr' size='340' side='right'caption='[[1fbr]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1fbr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FBR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FBR FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fbr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fbr OCA], [https://pdbe.org/1fbr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fbr RCSB], [https://www.ebi.ac.uk/pdbsum/1fbr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fbr ProSAT]</span></td></tr>
-{{STRUCTURE_1fbr|  PDB=1fbr  |  SCENE=  }}
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/FINC_HUMAN FINC_HUMAN] Defects in FN1 are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2) [MIM:[https://omim.org/entry/601894 601894]; also known as familial glomerular nephritis with fibronectin deposits or fibronectin glomerulopathy. GFND is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life.<ref>PMID:18268355</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/FINC_HUMAN FINC_HUMAN] Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape.<ref>PMID:8114919</ref> <ref>PMID:11209058</ref> <ref>PMID:15665290</ref> <ref>PMID:19379667</ref>   Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.<ref>PMID:8114919</ref> <ref>PMID:11209058</ref> <ref>PMID:15665290</ref> <ref>PMID:19379667</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fb/1fbr_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fbr ConSurf].
+<div style="clear:both"></div>
-===FOURTH AND FIFTH FIBRONECTIN TYPE I MODULE PAIR===
+==See Also==
+*[[Fibronectin 3D structures|Fibronectin 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_8308892}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 8308892 is the PubMed ID number.
+</StructureSection>
--->
-{{ABSTRACT_PUBMED_8308892}}
-==About this Structure==
-FBR is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FBR OCA].
-==Reference==
-<ref group="xtra">PMID:8308892</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Campbell, I D.]]
+[[Category: Large Structures]]
-[[Category: Phan, I Q.H.]]
+[[Category: Campbell ID]]
-[[Category: Williams, M J.]]
+[[Category: Phan IQH]]
-[[Category: Cell adhesion protein]]
+[[Category: Williams MJ]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 05:09:44 2009''