1elr: Difference between revisions

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[[Image:1elr.png|left|200px]]


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==Crystal structure of the TPR2A domain of HOP in complex with the HSP90 peptide MEEVD==
The line below this paragraph, containing "STRUCTURE_1elr", creates the "Structure Box" on the page.
<StructureSection load='1elr' size='340' side='right'caption='[[1elr]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1elr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ELR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ELR FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
{{STRUCTURE_1elr| PDB=1elr |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1elr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1elr OCA], [https://pdbe.org/1elr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1elr RCSB], [https://www.ebi.ac.uk/pdbsum/1elr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1elr ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/STIP1_HUMAN STIP1_HUMAN] Mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/el/1elr_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1elr ConSurf].
<div style="clear:both"></div>


===Crystal structure of the TPR2A domain of HOP in complex with the HSP90 peptide MEEVD===
==See Also==
 
*[[HOP protein|HOP protein]]
 
__TOC__
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</StructureSection>
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{{ABSTRACT_PUBMED_10786835}}
 
==About this Structure==
1ELR is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ELR OCA].
 
==Reference==
<ref group="xtra">PMID:10786835</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Brinker, A.]]
[[Category: Large Structures]]
[[Category: Hartl, F U.]]
[[Category: Brinker A]]
[[Category: Moarefi, I.]]
[[Category: Hartl FU]]
[[Category: Scheufler, C.]]
[[Category: Moarefi I]]
[[Category: Helical repeat]]
[[Category: Scheufler C]]
[[Category: Hop]]
[[Category: Hsp90]]
[[Category: Peptide-complex]]
[[Category: Protein binding]]
[[Category: Tpr-domain]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 03:16:39 2009''

Latest revision as of 13:04, 20 March 2024

Crystal structure of the TPR2A domain of HOP in complex with the HSP90 peptide MEEVDCrystal structure of the TPR2A domain of HOP in complex with the HSP90 peptide MEEVD

Structural highlights

1elr is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

STIP1_HUMAN Mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1elr, resolution 1.90Å

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