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==Crystal structure of the TPR2A domain of HOP in complex with the HSP90 peptide MEEVD== | |||
<StructureSection load='1elr' size='340' side='right'caption='[[1elr]], [[Resolution|resolution]] 1.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1elr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ELR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ELR FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1elr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1elr OCA], [https://pdbe.org/1elr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1elr RCSB], [https://www.ebi.ac.uk/pdbsum/1elr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1elr ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/STIP1_HUMAN STIP1_HUMAN] Mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB). | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/el/1elr_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1elr ConSurf]. | |||
<div style="clear:both"></div> | |||
== | ==See Also== | ||
*[[HOP protein|HOP protein]] | |||
__TOC__ | |||
</StructureSection> | |||
[[ | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Brinker | [[Category: Large Structures]] | ||
[[Category: Hartl | [[Category: Brinker A]] | ||
[[Category: Moarefi | [[Category: Hartl FU]] | ||
[[Category: Scheufler | [[Category: Moarefi I]] | ||
[[Category: Scheufler C]] | |||
Latest revision as of 13:04, 20 March 2024
Crystal structure of the TPR2A domain of HOP in complex with the HSP90 peptide MEEVDCrystal structure of the TPR2A domain of HOP in complex with the HSP90 peptide MEEVD
Structural highlights
FunctionSTIP1_HUMAN Mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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