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[[Image:1el0.gif|left|200px]]


{{Structure
==SOLUTION STRUCTURE OF THE HUMAN CC CHEMOKINE, I-309==
|PDB= 1el0 |SIZE=350|CAPTION= <scene name='initialview01'>1el0</scene>
<StructureSection load='1el0' size='340' side='right'caption='[[1el0]]' scene=''>
|SITE=
== Structural highlights ==
|LIGAND=
<table><tr><td colspan='2'>[[1el0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EL0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EL0 FirstGlance]. <br>
|ACTIVITY=
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
|GENE=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1el0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1el0 OCA], [https://pdbe.org/1el0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1el0 RCSB], [https://www.ebi.ac.uk/pdbsum/1el0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1el0 ProSAT]</span></td></tr>
}}
</table>
 
== Function ==
'''SOLUTION STRUCTURE OF THE HUMAN CC CHEMOKINE, I-309'''
[https://www.uniprot.org/uniprot/CCL1_HUMAN CCL1_HUMAN] Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8.<ref>PMID:1557400</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==Overview==
Check<jmol>
I-309 is a member of the CC subclass of chemokines and is one of only three human chemokines known to contain an additional, third disulfide bond. The three-dimensional solution structure of I-309 was determined by (1)H nuclear magnetic resonance spectroscopy and dynamic simulated annealing. The structure of I-309, which remains monomeric at high concentrations, was determined on the basis of 978 experimental restraints. The N-terminal region of I-309 was disordered, as has been previously observed for the CC chemokine eotaxin but not others such as MCP-1 and RANTES. This was followed in I-309 by a well-ordered region between residues 13 and 69 that consisted of a 3(10)-helix, a triple-stranded antiparallel beta-sheet, and finally a C-terminal alpha-helix. Root-mean-square deviations of 0.61 and 1.16 were observed for the backbone and heavy atoms, respectively. A comparison of I-309 to eotaxin and HCC-2 revealed a significant structural change in the C-terminal region of the protein. The alpha-helix normally present in chemokines was terminated early and was followed by a short section of extended strand. These changes were a direct result of the additional disulfide bond present in this protein. An examination of the I-309 structure will aid in an understanding of the specificity of this protein with its receptor, CCR8.
  <jmolCheckbox>
 
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/el/1el0_consurf.spt"</scriptWhenChecked>
==Disease==
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
Known diseases associated with this structure: Asthma, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601156 601156]], HIV1, resistance to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601156 601156]]
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1el0 ConSurf].
1EL0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EL0 OCA].  
<div style="clear:both"></div>
 
== References ==
==Reference==
<references/>
Human CC chemokine I-309, structural consequences of the additional disulfide bond., Keizer DW, Crump MP, Lee TW, Slupsky CM, Clark-Lewis I, Sykes BD, Biochemistry. 2000 May 23;39(20):6053-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10821677 10821677]
__TOC__
[[Category: Single protein]]
</StructureSection>
[[Category: Clark-Lewis, I.]]
[[Category: Homo sapiens]]
[[Category: Crump, M P.]]
[[Category: Large Structures]]
[[Category: Keizer, D W.]]
[[Category: Clark-Lewis I]]
[[Category: Lee, T W.]]
[[Category: Crump MP]]
[[Category: Slupsky, C M.]]
[[Category: Keizer DW]]
[[Category: Sykes, B D.]]
[[Category: Lee TW]]
[[Category: chemokine fold]]
[[Category: Slupsky CM]]
 
[[Category: Sykes BD]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:57:04 2008''

Latest revision as of 13:03, 20 March 2024

SOLUTION STRUCTURE OF THE HUMAN CC CHEMOKINE, I-309SOLUTION STRUCTURE OF THE HUMAN CC CHEMOKINE, I-309

Structural highlights

1el0 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CCL1_HUMAN Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Miller MD, Krangel MS. The human cytokine I-309 is a monocyte chemoattractant. Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):2950-4. PMID:1557400
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