1egx: Difference between revisions

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-[[Image:1egx.png|left|200px]]
-{{STRUCTURE_1egx|  PDB=1egx  |  SCENE=  }}
+==SOLUTION STRUCTURE OF THE ENA-VASP HOMOLOGY 1 (EVH1) DOMAIN OF HUMAN VASODILATOR-STIMULATED PHOSPHOPROTEIN (VASP)==
+<StructureSection load='1egx' size='340' side='right'caption='[[1egx]]' scene=''>
-===SOLUTION STRUCTURE OF THE ENA-VASP HOMOLOGY 1 (EVH1) DOMAIN OF HUMAN VASODILATOR-STIMULATED PHOSPHOPROTEIN (VASP)===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1egx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EGX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EGX FirstGlance]. <br>
-{{ABSTRACT_PUBMED_10990454}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1egx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1egx OCA], [https://pdbe.org/1egx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1egx RCSB], [https://www.ebi.ac.uk/pdbsum/1egx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1egx ProSAT]</span></td></tr>
-==About this Structure==
+</table>
-[[1egx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EGX OCA].
+== Function ==
+[https://www.uniprot.org/uniprot/VASP_HUMAN VASP_HUMAN] Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation.<ref>PMID:7828592</ref> <ref>PMID:10087267</ref> <ref>PMID:10438535</ref> <ref>PMID:15939738</ref> <ref>PMID:17082196</ref> <ref>PMID:18559661</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eg/1egx_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1egx ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Group:MUZIC:Mena VASP|MUZIC:Mena VASP]]
+*[[Vasodilator-stimulated phosphoprotein|Vasodilator-stimulated phosphoprotein]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:010990454</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Ball, L.]]
+[[Category: Large Structures]]
-[[Category: Hafner, A.]]
+[[Category: Ball L]]
-[[Category: Hof, M.]]
+[[Category: Hafner A]]
-[[Category: Hoffmann, B.]]
+[[Category: Hof M]]
-[[Category: Jarchau, T.]]
+[[Category: Hoffmann B]]
-[[Category: Kuhne, R.]]
+[[Category: Jarchau T]]
-[[Category: Oschkinat, H.]]
+[[Category: Kuhne R]]
-[[Category: Schmieder, P.]]
+[[Category: Oschkinat H]]
-[[Category: Schneider-Mergener, J.]]
+[[Category: Schmieder P]]
-[[Category: Volkmer-Engert, R.]]
+[[Category: Schneider-Mergener J]]
-[[Category: Wahl, M.]]
+[[Category: Volkmer-Engert R]]
-[[Category: Walter, U.]]
+[[Category: Wahl M]]
-[[Category: Evh1]]
+[[Category: Walter U]]
-[[Category: Poly-proline-binding domain]]
+[[Category: Z-disk]]
-[[Category: Signaling protein]]
-[[Category: Vasp-ena]]