1e17: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-{{Seed}}
-[[Image:1e17.png|left|200px]]
-<!--
+==Solution structure of the DNA binding domain of the human Forkhead transcription factor AFX (FOXO4)==
-The line below this paragraph, containing "STRUCTURE_1e17", creates the "Structure Box" on the page.
+<StructureSection load='1e17' size='340' side='right'caption='[[1e17]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1e17]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E17 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E17 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e17 OCA], [https://pdbe.org/1e17 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e17 RCSB], [https://www.ebi.ac.uk/pdbsum/1e17 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e17 ProSAT]</span></td></tr>
-{{STRUCTURE_1e17|  PDB=1e17  |  SCENE=  }}
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/FOXO4_HUMAN FOXO4_HUMAN] A chromosomal aberration involving FOXO4 is found in acute leukemias. Translocation t(X;11)(q13;q23) with KMT2A/MLL1. The result is a rogue activator protein.
+== Function ==
+[https://www.uniprot.org/uniprot/FOXO4_HUMAN FOXO4_HUMAN] Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity.<ref>PMID:10217147</ref> <ref>PMID:10783894</ref> <ref>PMID:12761217</ref> <ref>PMID:15126506</ref> <ref>PMID:16054032</ref> <ref>PMID:16964248</ref> <ref>PMID:20874444</ref> <ref>PMID:22972301</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e1/1e17_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1e17 ConSurf].
+<div style="clear:both"></div>
-===SOLUTION STRUCTURE OF THE DNA BINDING DOMAIN OF THE HUMAN FORKHEAD TRANSCRIPTION FACTOR AFX (FOXO4)===
+==See Also==
+*[[FOX 3D structures|FOX 3D structures]]
+== References ==
-==About this Structure==
+<references/>
-E17 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E17 OCA].
+__TOC__
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:10921784</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Climent, I.]]
+[[Category: Large Structures]]
-[[Category: Dahlman-Wright, K.]]
+[[Category: Climent I]]
-[[Category: Weigelt, J.]]
+[[Category: Dahlman-Wright K]]
-[[Category: Wikstrom, M.]]
+[[Category: Weigelt J]]
-[[Category: Dna binding domain]]
+[[Category: Wikstrom M]]
-[[Category: Winged helix]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:40:40 2009''