1dt7: Difference between revisions

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-[[Image:1dt7.png|left|200px]]
-{{STRUCTURE_1dt7|  PDB=1dt7  |  SCENE=  }}
+==SOLUTION STRUCTURE OF THE C-TERMINAL NEGATIVE REGULATORY DOMAIN OF P53 IN A COMPLEX WITH CA2+-BOUND S100B(BB)==
+<StructureSection load='1dt7' size='340' side='right'caption='[[1dt7]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1dt7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DT7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DT7 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dt7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dt7 OCA], [https://pdbe.org/1dt7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dt7 RCSB], [https://www.ebi.ac.uk/pdbsum/1dt7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dt7 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/S100B_RAT S100B_RAT] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization.<ref>PMID:19910580</ref> <ref>PMID:20351179</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dt/1dt7_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dt7 ConSurf].
+<div style="clear:both"></div>
-===SOLUTION STRUCTURE OF THE C-TERMINAL NEGATIVE REGULATORY DOMAIN OF P53 IN A COMPLEX WITH CA2+-BOUND S100B(BB)===
+==See Also==
+*[[S100 proteins 3D structures|S100 proteins 3D structures]]
-{{ABSTRACT_PUBMED_10876243}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[1dt7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DT7 OCA].
+</StructureSection>
+[[Category: Homo sapiens]]
-==Reference==
+[[Category: Large Structures]]
-<ref group="xtra">PMID:010876243</ref><references group="xtra"/>
 [[Category: Rattus norvegicus]]
-[[Category: Baldisseri, D M.]]
+[[Category: Baldisseri DM]]
-[[Category: Rustandi, R R.]]
+[[Category: Rustandi RR]]
-[[Category: Weber, D J.]]
+[[Category: Weber DJ]]
-[[Category: C-terminal domain of p53]]
-[[Category: Calcium-binding]]
-[[Category: Ef-hand]]
-[[Category: Four helix bundle]]
-[[Category: Helix loop helix]]
-[[Category: P53]]
-[[Category: S100 protein]]
-[[Category: S100b]]
-[[Category: Signaling protein]]