1dhm: Difference between revisions

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{{Seed}}
[[Image:1dhm.png|left|200px]]


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==DNA-BINDING DOMAIN OF E2 FROM HUMAN PAPILLOMAVIRUS-31, NMR, MINIMIZED AVERAGE STRUCTURE==
The line below this paragraph, containing "STRUCTURE_1dhm", creates the "Structure Box" on the page.
<StructureSection load='1dhm' size='340' side='right'caption='[[1dhm]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1dhm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_papillomavirus_31 Human papillomavirus 31]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DHM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DHM FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dhm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dhm OCA], [https://pdbe.org/1dhm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dhm RCSB], [https://www.ebi.ac.uk/pdbsum/1dhm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dhm ProSAT]</span></td></tr>
{{STRUCTURE_1dhm| PDB=1dhm |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/VE2_HPV31 VE2_HPV31] E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dh/1dhm_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dhm ConSurf].
<div style="clear:both"></div>


===DNA-BINDING DOMAIN OF E2 FROM HUMAN PAPILLOMAVIRUS-31, NMR, MINIMIZED AVERAGE STRUCTURE===
==See Also==
 
*[[Regulatory protein E2|Regulatory protein E2]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_8652551}}, adds the Publication Abstract to the page
[[Category: Human papillomavirus 31]]
(as it appears on PubMed at http://www.pubmed.gov), where 8652551 is the PubMed ID number.
[[Category: Large Structures]]
-->
[[Category: Egan DA]]
{{ABSTRACT_PUBMED_8652551}}
[[Category: Fesik SW]]
 
[[Category: Holzman TF]]
==About this Structure==
[[Category: Liang H]]
1DHM is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DHM OCA].
[[Category: Meadows RP]]
 
[[Category: Petros AP]]
==Reference==
[[Category: Robins T]]
<ref group="xtra">PMID:8652551</ref><references group="xtra"/>
[[Category: Walter K]]
[[Category: Human papillomavirus]]
[[Category: Yoon HS]]
[[Category: Egan, D A.]]
[[Category: Fesik, S W.]]
[[Category: Holzman, T F.]]
[[Category: Liang, H.]]
[[Category: Meadows, R P.]]
[[Category: Petros, A P.]]
[[Category: Robins, T.]]
[[Category: Walter, K.]]
[[Category: Yoon, H S.]]
[[Category: Dna-binding protein]]
[[Category: Early protein]]
[[Category: Trans-acting factor]]
[[Category: Transcriptional activator]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 22:08:39 2009''

Latest revision as of 12:50, 20 March 2024

DNA-BINDING DOMAIN OF E2 FROM HUMAN PAPILLOMAVIRUS-31, NMR, MINIMIZED AVERAGE STRUCTUREDNA-BINDING DOMAIN OF E2 FROM HUMAN PAPILLOMAVIRUS-31, NMR, MINIMIZED AVERAGE STRUCTURE

Structural highlights

1dhm is a 2 chain structure with sequence from Human papillomavirus 31. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

VE2_HPV31 E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

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