6psn: Difference between revisions
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==Anthrax toxin protective antigen channels bound to lethal factor== | |||
<SX load='6psn' size='340' side='right' viewer='molstar' caption='[[6psn]], [[Resolution|resolution]] 4.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6psn]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PSN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PSN FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.6Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6psn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6psn OCA], [https://pdbe.org/6psn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6psn RCSB], [https://www.ebi.ac.uk/pdbsum/6psn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6psn ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PAG_BACAN PAG_BACAN] One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. PA binds to a receptor (ATR) in sensitive eukaryotic cells, thereby facilitating the translocation of the enzymatic toxin components, edema factor and lethal factor, across the target cell membrane. PA associated with LF causes death when injected, PA associated with EF produces edema. PA induces immunity to infection with anthrax. | |||
==See Also== | |||
*[[Anthrax lethal factor 3D structures|Anthrax lethal factor 3D structures]] | |||
__TOC__ | |||
[[Category: | </SX> | ||
[[Category: Bacillus anthracis]] | |||
[[Category: Large Structures]] | |||
[[Category: Hardenbrook NJ]] | |||
[[Category: Krantz BA]] | |||
[[Category: Liu S]] | |||
[[Category: Zhou K]] | |||
[[Category: Zhou ZH]] | |||
Latest revision as of 12:27, 20 March 2024
Anthrax toxin protective antigen channels bound to lethal factorAnthrax toxin protective antigen channels bound to lethal factor
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