6p07: Difference between revisions

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==Spastin hexamer in complex with substrate==
==Spastin hexamer in complex with substrate==
<StructureSection load='6p07' size='340' side='right'caption='[[6p07]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<SX load='6p07' size='340' side='right' viewer='molstar' caption='[[6p07]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6p07]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P07 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6P07 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6p07]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P07 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6P07 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">spas, D-spastin, Dmel\CG5977, Dspastin, Spas, Spastin, CG5977, Dmel_CG5977 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Microtubule-severing_ATPase Microtubule-severing ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.6.1.1 5.6.1.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6p07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p07 OCA], [https://pdbe.org/6p07 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6p07 RCSB], [https://www.ebi.ac.uk/pdbsum/6p07 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6p07 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6p07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p07 OCA], [http://pdbe.org/6p07 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6p07 RCSB], [http://www.ebi.ac.uk/pdbsum/6p07 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6p07 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/A0A126GV13_DROME A0A126GV13_DROME]] ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing.[HAMAP-Rule:MF_03021]  
[https://www.uniprot.org/uniprot/A0A0B4LHJ5_DROME A0A0B4LHJ5_DROME] ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing.[HAMAP-Rule:MF_03021]
__TOC__
__TOC__
</StructureSection>
</SX>
[[Category: Drome]]
[[Category: Drosophila melanogaster]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Microtubule-severing ATPase]]
[[Category: Lander GC]]
[[Category: Lander, G C]]
[[Category: Roll-Mecak A]]
[[Category: Roll-Mecak, A]]
[[Category: Sandate CR]]
[[Category: Sandate, C R]]
[[Category: Szyk A]]
[[Category: Szyk, A]]
[[Category: Zehr E]]
[[Category: Zehr, E]]
[[Category: Aaa+ atpase]]
[[Category: Homohexamer]]
[[Category: Microtubule severing enzyme]]
[[Category: Motor protein]]

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