6ikm: Difference between revisions

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'''Unreleased structure'''


The entry 6ikm is ON HOLD
==Crystal structure of SpuE-Spermidine in complex with ScFv5==
<StructureSection load='6ikm' size='340' side='right'caption='[[6ikm]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6ikm]] is a 36 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IKM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IKM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.398&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SPD:SPERMIDINE'>SPD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ikm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ikm OCA], [https://pdbe.org/6ikm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ikm RCSB], [https://www.ebi.ac.uk/pdbsum/6ikm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ikm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SPUE_PSEAE SPUE_PSEAE] Spermidine-binding protein probably required for its uptake into cells. Binds spermidine with high affinity (KD=14.3 nM). Does not bind putrescine, cadaverine or spermine. Spermidine binding induces large inter-domain conformational changes. Implicated in induction of type 3 secretion systems (T3SS), which play a role in virulence.<ref>PMID:22300763</ref>


Authors:  
==See Also==
 
*[[Antibody 3D structures|Antibody 3D structures]]
Description:  
== References ==
[[Category: Unreleased Structures]]
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Sun X]]
[[Category: Wu D]]

Latest revision as of 12:20, 20 March 2024

Crystal structure of SpuE-Spermidine in complex with ScFv5Crystal structure of SpuE-Spermidine in complex with ScFv5

Structural highlights

6ikm is a 36 chain structure with sequence from Homo sapiens and Pseudomonas aeruginosa. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.398Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SPUE_PSEAE Spermidine-binding protein probably required for its uptake into cells. Binds spermidine with high affinity (KD=14.3 nM). Does not bind putrescine, cadaverine or spermine. Spermidine binding induces large inter-domain conformational changes. Implicated in induction of type 3 secretion systems (T3SS), which play a role in virulence.[1]

See Also

References

  1. ↑ Wu D, Lim SC, Dong Y, Wu J, Tao F, Zhou L, Zhang LH, Song H. Structural Basis of Substrate Binding Specificity Revealed by the Crystal Structures of Polyamine Receptors SpuD and SpuE from Pseudomonas aeruginosa. J Mol Biol. 2012 Mar 9;416(5):697-712. Epub 2012 Jan 28. PMID:22300763 doi:10.1016/j.jmb.2012.01.010

6ikm, resolution 3.40Å

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