5gpd: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
m Protected "5gpd" [edit=sysop:move=sysop]
No edit summary
 
(3 intermediate revisions by the same user not shown)
Line 1: Line 1:
'''Unreleased structure'''


The entry 5gpd is ON HOLD
==Crystal structure of the binding domain of SREBP from fission yeast==
 
<StructureSection load='5gpd' size='340' side='right'caption='[[5gpd]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5gpd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GPD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GPD FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.501&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gpd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gpd OCA], [https://pdbe.org/5gpd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gpd RCSB], [https://www.ebi.ac.uk/pdbsum/5gpd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gpd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SREBP_SCHPO SREBP_SCHPO] Transcriptional activator required for transcription of genes required for adaptation to anaerobic growth like those implicated in the nonrespiratory oxygen-consumptive biosynthetic pathways of sterol, heme, sphingolipid, and ubiquinone biosynthesis. May monitor oxygen levels through sterol synthesis steps which require oxygen.<ref>PMID:15797383</ref> <ref>PMID:16537923</ref> <ref>PMID:18276645</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Schizosaccharomyces pombe 972h-]]
[[Category: Gong X]]
[[Category: Qian HW]]
[[Category: Wu JP]]
[[Category: Yan N]]

Latest revision as of 12:13, 20 March 2024

Crystal structure of the binding domain of SREBP from fission yeastCrystal structure of the binding domain of SREBP from fission yeast

Structural highlights

5gpd is a 2 chain structure with sequence from Schizosaccharomyces pombe 972h-. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.501Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SREBP_SCHPO Transcriptional activator required for transcription of genes required for adaptation to anaerobic growth like those implicated in the nonrespiratory oxygen-consumptive biosynthetic pathways of sterol, heme, sphingolipid, and ubiquinone biosynthesis. May monitor oxygen levels through sterol synthesis steps which require oxygen.[1] [2] [3]

References

  1. ↑ Hughes AL, Todd BL, Espenshade PJ. SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast. Cell. 2005 Mar 25;120(6):831-42. PMID:15797383 doi:http://dx.doi.org/10.1016/j.cell.2005.01.012
  2. ↑ Todd BL, Stewart EV, Burg JS, Hughes AL, Espenshade PJ. Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast. Mol Cell Biol. 2006 Apr;26(7):2817-31. PMID:16537923 doi:http://dx.doi.org/10.1128/MCB.26.7.2817-2831.2006
  3. ↑ Sehgal A, Hughes BT, Espenshade PJ. Oxygen-dependent, alternative promoter controls translation of tco1+ in fission yeast. Nucleic Acids Res. 2008 Apr;36(6):2024-31. doi: 10.1093/nar/gkn027. Epub 2008 Feb, 14. PMID:18276645 doi:http://dx.doi.org/10.1093/nar/gkn027

5gpd, resolution 3.50Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=5gpd&oldid=4106039"