5gpd: Difference between revisions

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New page: '''Unreleased structure''' The entry 5gpd is ON HOLD Authors: Description: Category: Unreleased Structures
 
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'''Unreleased structure'''


The entry 5gpd is ON HOLD
==Crystal structure of the binding domain of SREBP from fission yeast==
 
<StructureSection load='5gpd' size='340' side='right'caption='[[5gpd]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5gpd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GPD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GPD FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.501&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gpd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gpd OCA], [https://pdbe.org/5gpd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gpd RCSB], [https://www.ebi.ac.uk/pdbsum/5gpd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gpd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SREBP_SCHPO SREBP_SCHPO] Transcriptional activator required for transcription of genes required for adaptation to anaerobic growth like those implicated in the nonrespiratory oxygen-consumptive biosynthetic pathways of sterol, heme, sphingolipid, and ubiquinone biosynthesis. May monitor oxygen levels through sterol synthesis steps which require oxygen.<ref>PMID:15797383</ref> <ref>PMID:16537923</ref> <ref>PMID:18276645</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Schizosaccharomyces pombe 972h-]]
[[Category: Gong X]]
[[Category: Qian HW]]
[[Category: Wu JP]]
[[Category: Yan N]]

Latest revision as of 12:13, 20 March 2024

Crystal structure of the binding domain of SREBP from fission yeastCrystal structure of the binding domain of SREBP from fission yeast

Structural highlights

5gpd is a 2 chain structure with sequence from Schizosaccharomyces pombe 972h-. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.501Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SREBP_SCHPO Transcriptional activator required for transcription of genes required for adaptation to anaerobic growth like those implicated in the nonrespiratory oxygen-consumptive biosynthetic pathways of sterol, heme, sphingolipid, and ubiquinone biosynthesis. May monitor oxygen levels through sterol synthesis steps which require oxygen.[1] [2] [3]

References

  1. ↑ Hughes AL, Todd BL, Espenshade PJ. SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast. Cell. 2005 Mar 25;120(6):831-42. PMID:15797383 doi:http://dx.doi.org/10.1016/j.cell.2005.01.012
  2. ↑ Todd BL, Stewart EV, Burg JS, Hughes AL, Espenshade PJ. Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast. Mol Cell Biol. 2006 Apr;26(7):2817-31. PMID:16537923 doi:http://dx.doi.org/10.1128/MCB.26.7.2817-2831.2006
  3. ↑ Sehgal A, Hughes BT, Espenshade PJ. Oxygen-dependent, alternative promoter controls translation of tco1+ in fission yeast. Nucleic Acids Res. 2008 Apr;36(6):2024-31. doi: 10.1093/nar/gkn027. Epub 2008 Feb, 14. PMID:18276645 doi:http://dx.doi.org/10.1093/nar/gkn027

5gpd, resolution 3.50Å

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