5ggt: Difference between revisions

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New page: '''Unreleased structure''' The entry 5ggt is ON HOLD Authors: Heo, Y.S. Description: PD-L1 in complex with BMS-936559 Fab Category: Unreleased Structures Category: Heo, Y.S
 
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'''Unreleased structure'''


The entry 5ggt is ON HOLD
==PD-L1 in complex with BMS-936559 Fab==
 
<StructureSection load='5ggt' size='340' side='right'caption='[[5ggt]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
Authors: Heo, Y.S.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5ggt]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GGT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GGT FirstGlance]. <br>
Description: PD-L1 in complex with BMS-936559 Fab
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ggt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ggt OCA], [https://pdbe.org/5ggt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ggt RCSB], [https://www.ebi.ac.uk/pdbsum/5ggt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ggt ProSAT]</span></td></tr>
[[Category: Heo, Y.S]]
</table>
== Function ==
[https://www.uniprot.org/uniprot/PD1L1_HUMAN PD1L1_HUMAN] Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.<ref>PMID:10581077</ref> <ref>PMID:11015443</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Heo YS]]

Latest revision as of 12:12, 20 March 2024

PD-L1 in complex with BMS-936559 FabPD-L1 in complex with BMS-936559 Fab

Structural highlights

5ggt is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.8Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PD1L1_HUMAN Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.[1] [2]

References

  1. ↑ Dong H, Zhu G, Tamada K, Chen L. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat Med. 1999 Dec;5(12):1365-9. PMID:10581077 doi:10.1038/70932
  2. ↑ Freeman GJ, Long AJ, Iwai Y, Bourque K, Chernova T, Nishimura H, Fitz LJ, Malenkovich N, Okazaki T, Byrne MC, Horton HF, Fouser L, Carter L, Ling V, Bowman MR, Carreno BM, Collins M, Wood CR, Honjo T. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med. 2000 Oct 2;192(7):1027-34. PMID:11015443

5ggt, resolution 2.80Å

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