5f59: Difference between revisions

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-'''Unreleased structure'''
-The entry 5f59 is ON HOLD  until Paper Publication
+==The crystal structure of MLL3 SET domain==
+<StructureSection load='5f59' size='340' side='right'caption='[[5f59]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5f59]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F59 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5F59 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.801&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5f59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f59 OCA], [https://pdbe.org/5f59 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5f59 RCSB], [https://www.ebi.ac.uk/pdbsum/5f59 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5f59 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/KMT2C_HUMAN KMT2C_HUMAN] Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder.<ref>PMID:17500065</ref>
-Authors: Li, Y., Lei, M., Chen, Y.
+==See Also==
+*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
-Description: The crystal structure of MLL3 SET domain
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Li, Y]]
+__TOC__
-[[Category: Chen, Y]]
+</StructureSection>
-[[Category: Lei, M]]
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Chen Y]]
+[[Category: Lei M]]
+[[Category: Li Y]]