5eqj: Difference between revisions

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New page: '''Unreleased structure''' The entry 5eqj is ON HOLD Authors: Zhu, Y., Wang, M., Wang, C., Fan, X., Jiang, X., Teng, M., Li, X. Description: Crystal structure of the two-subunit tRNA m...
 
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'''Unreleased structure'''


The entry 5eqj is ON HOLD
==Crystal structure of the two-subunit tRNA m1A58 methyltransferase from Saccharomyces cerevisiae==
<StructureSection load='5eqj' size='340' side='right'caption='[[5eqj]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5eqj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EQJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EQJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5eqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eqj OCA], [https://pdbe.org/5eqj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5eqj RCSB], [https://www.ebi.ac.uk/pdbsum/5eqj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5eqj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TRM6_YEAST TRM6_YEAST] Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. Binds RNA. Also required for repression of GCN4 mRNA translation by the upstream open reading frames (uORFs) under conditions of amino acid sufficiency.<ref>PMID:10779558</ref> <ref>PMID:7542616</ref> <ref>PMID:9851972</ref>


Authors: Zhu, Y., Wang, M., Wang, C., Fan, X., Jiang, X., Teng, M., Li, X.
==See Also==
 
*[[TRNA methyltransferase 3D structures|TRNA methyltransferase 3D structures]]
Description: Crystal structure of the two-subunit tRNA m1A58 methyltransferase from Saccharomyces cerevisiae
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Wang, M]]
__TOC__
[[Category: Jiang, X]]
</StructureSection>
[[Category: Teng, M]]
[[Category: Large Structures]]
[[Category: Zhu, Y]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Li, X]]
[[Category: Fan X]]
[[Category: Wang, C]]
[[Category: Jiang X]]
[[Category: Fan, X]]
[[Category: Li X]]
[[Category: Teng M]]
[[Category: Wang C]]
[[Category: Wang M]]
[[Category: Zhu Y]]

Latest revision as of 12:11, 20 March 2024

Crystal structure of the two-subunit tRNA m1A58 methyltransferase from Saccharomyces cerevisiaeCrystal structure of the two-subunit tRNA m1A58 methyltransferase from Saccharomyces cerevisiae

Structural highlights

5eqj is a 2 chain structure with sequence from Saccharomyces cerevisiae S288C. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TRM6_YEAST Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. Binds RNA. Also required for repression of GCN4 mRNA translation by the upstream open reading frames (uORFs) under conditions of amino acid sufficiency.[1] [2] [3]

See Also

References

  1. ↑ Anderson J, Phan L, Hinnebusch AG. The Gcd10p/Gcd14p complex is the essential two-subunit tRNA(1-methyladenosine) methyltransferase of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2000 May 9;97(10):5173-8. PMID:10779558 doi:http://dx.doi.org/10.1073/pnas.090102597
  2. ↑ Garcia-Barrio MT, Naranda T, Vazquez de Aldana CR, Cuesta R, Hinnebusch AG, Hershey JW, Tamame M. GCD10, a translational repressor of GCN4, is the RNA-binding subunit of eukaryotic translation initiation factor-3. Genes Dev. 1995 Jul 15;9(14):1781-96. PMID:7542616
  3. ↑ Anderson J, Phan L, Cuesta R, Carlson BA, Pak M, Asano K, Bjork GR, Tamame M, Hinnebusch AG. The essential Gcd10p-Gcd14p nuclear complex is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA. Genes Dev. 1998 Dec 1;12(23):3650-62. PMID:9851972

5eqj, resolution 2.20Å

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