5dok: Difference between revisions
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==Crystal structure of Tetrahymena p45C== | |||
<StructureSection load='5dok' size='340' side='right'caption='[[5dok]], [[Resolution|resolution]] 2.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5dok]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetrahymena_thermophila Tetrahymena thermophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DOK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DOK FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dok OCA], [https://pdbe.org/5dok PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dok RCSB], [https://www.ebi.ac.uk/pdbsum/5dok PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dok ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TAP45_TETTS TAP45_TETTS] Component of a CST-like subcomplex of the holoenzyme telomerase ribonucleoprotein complex, which stimulates telomerase complementary-strand synthesis (PubMed:26551074). Telomerase is an essential ribonucleoprotein enzyme that copies new telomeric repeats onto chromosome ends by repetitively synthesizing the short telomere-repeat sequence 5'-TTGGGG-3' using an RNA template component TER (PubMed:26551074). The CST-like subcomplex (also named 7-4-1) binds telomeric single-stranded DNA and coordinates telomere G-strand and C-strand synthesis (PubMed:26551074).<ref>PMID:26551074</ref> | |||
==See Also== | |||
*[[Telomerase-associated protein|Telomerase-associated protein]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: Lei | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Tetrahymena thermophila]] | ||
[[Category: Lei M]] | |||
[[Category: Tang T]] | |||
[[Category: Wan B]] | |||
[[Category: Wu J]] | |||
Latest revision as of 12:10, 20 March 2024
Crystal structure of Tetrahymena p45CCrystal structure of Tetrahymena p45C
Structural highlights
FunctionTAP45_TETTS Component of a CST-like subcomplex of the holoenzyme telomerase ribonucleoprotein complex, which stimulates telomerase complementary-strand synthesis (PubMed:26551074). Telomerase is an essential ribonucleoprotein enzyme that copies new telomeric repeats onto chromosome ends by repetitively synthesizing the short telomere-repeat sequence 5'-TTGGGG-3' using an RNA template component TER (PubMed:26551074). The CST-like subcomplex (also named 7-4-1) binds telomeric single-stranded DNA and coordinates telomere G-strand and C-strand synthesis (PubMed:26551074).[1] See AlsoReferences
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