5dkw: Difference between revisions
New page: '''Unreleased structure''' The entry 5dkw is ON HOLD Authors: Liu, M.S., Tsai, M.D. Description: Category: Unreleased Structures Category: Liu, M.S Category: Tsai, M.D |
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==Ternary crystal structure of polymerase lambda with a GA mispair at the primer terminus with Ca2+ in the active== | |||
<StructureSection load='5dkw' size='340' side='right'caption='[[5dkw]], [[Resolution|resolution]] 2.69Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5dkw]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DKW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DKW FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.689Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DTP:2-DEOXYADENOSINE+5-TRIPHOSPHATE'>DTP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dkw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dkw OCA], [https://pdbe.org/5dkw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dkw RCSB], [https://www.ebi.ac.uk/pdbsum/5dkw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dkw ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DPOLL_HUMAN DPOLL_HUMAN] Repair polymerase. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Has both DNA polymerase and terminal transferase activities. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.<ref>PMID:11457865</ref> <ref>PMID:15537631</ref> | |||
==See Also== | |||
*[[DNA polymerase 3D structures|DNA polymerase 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: Liu | __TOC__ | ||
[[Category: Tsai | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Liu MS]] | |||
[[Category: Tsai MD]] | |||