5cpe: Difference between revisions

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-'''Unreleased structure'''
-The entry 5cpe is ON HOLD
+==Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand==
+<StructureSection load='5cpe' size='340' side='right'caption='[[5cpe]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5cpe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CPE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CPE FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.62&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EB2:N-CYCLOHEPTYL-1-ETHYL-2-OXO-1,2-DIHYDROBENZO[CD]INDOLE-6-SULFONAMIDE'>EB2</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cpe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cpe OCA], [https://pdbe.org/5cpe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cpe RCSB], [https://www.ebi.ac.uk/pdbsum/5cpe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cpe ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
-Authors: Zhang, Y., Song, M., Liu, Z., Xue, X.
+==See Also==
+*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
-Description: Crystal Structure Analysis of the BRD4(1)
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Zhang, Y]]
+__TOC__
-[[Category: Liu, Z]]
+</StructureSection>
-[[Category: Song, M]]
+[[Category: Homo sapiens]]
-[[Category: Xue, X]]
+[[Category: Large Structures]]
+[[Category: Liu Z]]
+[[Category: Song M]]
+[[Category: Xu Y]]
+[[Category: Xue X]]
+[[Category: Zhang Y]]