5c8y: Difference between revisions
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==Crystal structure of T2R-TTL-Plinabulin complex== | |||
<StructureSection load='5c8y' size='340' side='right'caption='[[5c8y]], [[Resolution|resolution]] 2.59Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5c8y]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus], [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Sus_barbatus Sus barbatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C8Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5C8Y FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.594Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PN6:(3Z,6Z)-3-BENZYLIDENE-6-[(5-TERT-BUTYL-1H-IMIDAZOL-4-YL)METHYLIDENE]PIPERAZINE-2,5-DIONE'>PN6</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5c8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c8y OCA], [https://pdbe.org/5c8y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5c8y RCSB], [https://www.ebi.ac.uk/pdbsum/5c8y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5c8y ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/A0A0R4I993_SUSBA A0A0R4I993_SUSBA] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.[RuleBase:RU000352][SAAS:SAAS00824325] | |||
==See Also== | |||
*[[Stathmin-4 3D structures|Stathmin-4 3D structures]] | |||
*[[Tubulin 3D Structures|Tubulin 3D Structures]] | |||
[[Category: | *[[Tubulin tyrosine ligase 3D structures|Tubulin tyrosine ligase 3D structures]] | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Gallus gallus]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Rattus norvegicus]] | |||
[[Category: Sus barbatus]] | |||
[[Category: Chen Q]] | |||
[[Category: Wang Y]] | |||
[[Category: Yang J]] | |||
[[Category: Yu Y]] | |||
Latest revision as of 12:08, 20 March 2024
Crystal structure of T2R-TTL-Plinabulin complexCrystal structure of T2R-TTL-Plinabulin complex
Structural highlights
FunctionA0A0R4I993_SUSBA Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.[RuleBase:RU000352][SAAS:SAAS00824325] See Also |
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