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==Structure of a mammalian 80S ribosome obtained by docking homology models of the RNA and proteins into an 8.7 A cryo-EM map==
==Structure of a mammalian 80S ribosome obtained by docking homology models of the RNA and proteins into an 8.7 A cryo-EM map==
<StructureSection load='4v5z' size='340' side='right'caption='[[4v5z]], [[Resolution|resolution]] 8.70&Aring;' scene=''>
<SX load='4v5z' size='340' side='right' viewer='molstar' caption='[[4v5z]], [[Resolution|resolution]] 8.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4v5z]] is a 86 chain structure with sequence from [http://en.wikipedia.org/wiki/Canis_familiaris Canis familiaris] and [http://en.wikipedia.org/wiki/Canis_familiaris Canis familiaris]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2zkq 2zkq] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2zkr 2zkr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V5Z FirstGlance]. <br>
<table><tr><td colspan='2'>[[4v5z]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2zkq 2zkq] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2zkr 2zkr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V5Z FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v5z OCA], [http://pdbe.org/4v5z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4v5z RCSB], [http://www.ebi.ac.uk/pdbsum/4v5z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4v5z ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 8.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v5z OCA], [https://pdbe.org/4v5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v5z RCSB], [https://www.ebi.ac.uk/pdbsum/4v5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v5z ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
In this paper, we present a structure of the mammalian ribosome determined at approximately 8.7 A resolution by electron cryomicroscopy and single-particle methods. A model of the ribosome was created by docking homology models of subunit rRNAs and conserved proteins into the density map. We then modeled expansion segments in the subunit rRNAs and found unclaimed density for approximately 20 proteins. In general, many conserved proteins and novel proteins interact with expansion segments to form an integrated framework that may stabilize the mature ribosome. Our structure provides a snapshot of the mammalian ribosome at the beginning of translation and lends support to current models in which large movements of the small subunit and L1 stalk occur during tRNA translocation. Finally, details are presented for intersubunit bridges that are specific to the eukaryotic ribosome. We suggest that these bridges may help reset the conformation of the ribosome to prepare for the next cycle of chain elongation.
Structure of the mammalian 80S ribosome at 8.7 A resolution.,Chandramouli P, Topf M, Menetret JF, Eswar N, Cannone JJ, Gutell RR, Sali A, Akey CW Structure. 2008 Apr;16(4):535-48. PMID:18400176<ref>PMID:18400176</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4v5z" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Receptor for activated protein kinase C 1|Receptor for activated protein kinase C 1]]
*[[Ribosome 3D structures|Ribosome 3D structures]]
*[[Ribosome 3D structures|Ribosome 3D structures]]
*[[Transfer RNA (tRNA)|Transfer RNA (tRNA)]]
*[[Transfer RNA (tRNA)|Transfer RNA (tRNA)]]
== References ==
*[[3D sructureseceptor for activated protein kinase C 1|3D sructureseceptor for activated protein kinase C 1]]
<references/>
__TOC__
__TOC__
</StructureSection>
</SX>
[[Category: Canis familiaris]]
[[Category: Canis lupus familiaris]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Akey, C W]]
[[Category: Akey CW]]
[[Category: Chandramouli, P]]
[[Category: Chandramouli P]]
[[Category: 40s ribosomal subunit]]
[[Category: Protein-rna complex]]
[[Category: Ribosomal protein-rna complex]]

Latest revision as of 12:01, 20 March 2024

Structure of a mammalian 80S ribosome obtained by docking homology models of the RNA and proteins into an 8.7 A cryo-EM mapStructure of a mammalian 80S ribosome obtained by docking homology models of the RNA and proteins into an 8.7 A cryo-EM map

4v5z, resolution 8.70Å

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