4u1b: Difference between revisions

Latest revision as of 12:00, 20 March 2024

HsMetAP in complex with (1-amino-2-propylpentyl)phosphonic acidHsMetAP in complex with (1-amino-2-propylpentyl)phosphonic acid

Structural highlights

4u1b is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.89Å
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MAP11_HUMAN Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle.[HAMAP-Rule:MF_03174]^[1] ^[2]

References

↑ Addlagatta A, Hu X, Liu JO, Matthews BW. Structural basis for the functional differences between type I and type II human methionine aminopeptidases. Biochemistry. 2005 Nov 15;44(45):14741-9. PMID:16274222 doi:10.1021/bi051691k
↑ Hu X, Addlagatta A, Lu J, Matthews BW, Liu JO. Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18148-53. Epub 2006 Nov 17. PMID:17114291

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OCA

[1] Addlagatta A, Hu X, Liu JO, Matthews BW. Structural basis for the functional differences between type I and type II human methionine aminopeptidases. Biochemistry. 2005 Nov 15;44(45):14741-9. PMID:16274222 doi:10.1021/bi051691k

[2] Hu X, Addlagatta A, Lu J, Matthews BW, Liu JO. Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18148-53. Epub 2006 Nov 17. PMID:17114291

[1]

[2]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4u1b is ON HOLD  until Paper Publication
+==HsMetAP in complex with (1-amino-2-propylpentyl)phosphonic acid==
+<StructureSection load='4u1b' size='340' side='right'caption='[[4u1b]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4u1b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U1B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U1B FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=Q08:[(1R)-1-AMINO-2-PROPYLPENTYL]PHOSPHONIC+ACID'>Q08</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u1b OCA], [https://pdbe.org/4u1b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u1b RCSB], [https://www.ebi.ac.uk/pdbsum/4u1b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u1b ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/MAP11_HUMAN MAP11_HUMAN] Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle.[HAMAP-Rule:MF_03174]<ref>PMID:16274222</ref> <ref>PMID:17114291</ref>
-Authors: Arya, T., Addlagatta, A.
+==See Also==
+*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]]
-Description: HsMetAP in complex with (1-amino-2-propylpentyl)phosphonic acid
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Addlagatta A]]
+[[Category: Arya T]]

4u1b: Difference between revisions

Latest revision as of 12:00, 20 March 2024

HsMetAP in complex with (1-amino-2-propylpentyl)phosphonic acidHsMetAP in complex with (1-amino-2-propylpentyl)phosphonic acid

Structural highlights

Function

See Also

References

Contents

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4u1b: Difference between revisions

Latest revision as of 12:00, 20 March 2024

HsMetAP in complex with (1-amino-2-propylpentyl)phosphonic acidHsMetAP in complex with (1-amino-2-propylpentyl)phosphonic acid

Structural highlights

Function

See Also

References

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