4ref: Difference between revisions

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'''Unreleased structure'''


The entry 4ref is ON HOLD  until Paper Publication
==Crystal Structure of TR3 LBD_L449W in complex with Molecule 2==
 
<StructureSection load='4ref' size='340' side='right'caption='[[4ref]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
Authors: Li, F.W., Cai, Q.X., Li, A.Z., Tian, X.Y., Wang, W.J., Yuan, W., Hou, P.P., Wu, Q., Lin, T.W.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4ref]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4REF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4REF FirstGlance]. <br>
Description: Crystal Structure of TR3 LBD_L449W in complex with Molecule 2
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3N0:1-(3,4,5-TRIHYDROXYPHENYL)HEXAN-1-ONE'>3N0</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ref FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ref OCA], [https://pdbe.org/4ref PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ref RCSB], [https://www.ebi.ac.uk/pdbsum/4ref PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ref ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NR4A1_HUMAN NR4A1_HUMAN] Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.<ref>PMID:15466594</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cai QX]]
[[Category: Hou PP]]
[[Category: Li AZ]]
[[Category: Li FW]]
[[Category: Lin TW]]
[[Category: Tian XY]]
[[Category: Wang WJ]]
[[Category: Wu Q]]
[[Category: Yuan W]]

Latest revision as of 11:59, 20 March 2024

Crystal Structure of TR3 LBD_L449W in complex with Molecule 2Crystal Structure of TR3 LBD_L449W in complex with Molecule 2

Structural highlights

4ref is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.1Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NR4A1_HUMAN Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.[1]

References

  1. ↑ Harant H, Lindley IJ. Negative cross-talk between the human orphan nuclear receptor Nur77/NAK-1/TR3 and nuclear factor-kappaB. Nucleic Acids Res. 2004 Oct 5;32(17):5280-90. Print 2004. PMID:15466594 doi:10.1093/nar/gkh856

4ref, resolution 2.10Å

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OCA
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