4qv2: Difference between revisions

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 ==Unliganded crystal structure of Feline Norovirus P Domain co-crystallized with HBGA A-trisaccharide==
-<StructureSection load='4qv2' size='340' side='right' caption='[[4qv2]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
+<StructureSection load='4qv2' size='340' side='right'caption='[[4qv2]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4qv2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QV2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QV2 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4qv2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Norovirus_cat/GIV.2/CU081210E/USA/2010 Norovirus cat/GIV.2/CU081210E/USA/2010]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QV2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QV2 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.68&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4quz|4quz]], [[4qva|4qva]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qv2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qv2 RCSB], [http://www.ebi.ac.uk/pdbsum/4qv2 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qv2 OCA], [https://pdbe.org/4qv2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qv2 RCSB], [https://www.ebi.ac.uk/pdbsum/4qv2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qv2 ProSAT]</span></td></tr>
 </table>
-<div style="background-color:#fffaf0;">
+== Function ==
-== Publication Abstract from PubMed ==
+[https://www.uniprot.org/uniprot/H8YRY9_9CALI H8YRY9_9CALI]
-Norovirus infects different animals, including humans, mice, dogs, and cats. Here, we show an X-ray crystal structure of a feline GIV.2 norovirus capsid-protruding (P) domain to 2.35A resolution. The feline GIV.2 P domain was reminiscent of human norovirus P domains, except for a novel P2 subdomain alpha-helix and an extended P1 subdomain interface loop. These new structural features likely obstructed histo-blood group antigens, which are attachment factors for human norovirus, from binding at the equivalent sites on the feline GIV.2 P domain. Additionally, an ELISA showed that the feline GIV.2 was antigenically distinct from a human GII.10 norovirus.
-Structural analysis of a feline norovirus protruding domain.,Singh BK, Glatt S, Ferrer JL, Koromyslova AD, Leuthold MM, Dunder J, Hansman GS Virology. 2015 Jan 1;474:181-5. doi: 10.1016/j.virol.2014.10.028. Epub 2014 Nov, 19. PMID:25463616<ref>PMID:25463616</ref>
-From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+==See Also==
-</div>
+*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
-== References ==
-<references/>
 __TOC__
 </StructureSection>
-[[Category: Hansman, G S]]
+[[Category: Large Structures]]
-[[Category: Singh, B K]]
+[[Category: Norovirus cat/GIV 2/CU081210E/USA/2010]]
-[[Category: Capsid protein]]
+[[Category: Hansman GS]]
-[[Category: Feline norovirus]]
+[[Category: Singh BK]]
-[[Category: P domain]]
-[[Category: Protruding domain]]
-[[Category: Viral protein]]