4qah: Difference between revisions

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-'''Unreleased structure'''
-The entry 4qah is ON HOLD
+==The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop==
+<StructureSection load='4qah' size='340' side='right'caption='[[4qah]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4qah]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QAH FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.403&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qah OCA], [https://pdbe.org/4qah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qah RCSB], [https://www.ebi.ac.uk/pdbsum/4qah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qah ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
-Authors: xiao.P, wang.X, wang.H.M, fu.X.L, cui.F.A, cui.F.A, bi.W.X, bi.W.X
+==See Also==
+*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
-Description: The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Bi WX]]
+[[Category: Cui FA]]
+[[Category: Fu XL]]
+[[Category: Wang HM]]
+[[Category: Wang X]]
+[[Category: Xiao P]]