4my5: Difference between revisions

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<StructureSection load='4my5' size='340' side='right'caption='[[4my5]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
<StructureSection load='4my5' size='340' side='right'caption='[[4my5]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4my5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Strmu Strmu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MY5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MY5 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4my5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_mutans_UA159 Streptococcus mutans UA159]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MY5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MY5 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SMU_24 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210007 STRMU])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.194&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4my5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4my5 OCA], [http://pdbe.org/4my5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4my5 RCSB], [http://www.ebi.ac.uk/pdbsum/4my5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4my5 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4my5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4my5 OCA], [https://pdbe.org/4my5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4my5 RCSB], [https://www.ebi.ac.uk/pdbsum/4my5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4my5 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/Q8DWM1_STRMU Q8DWM1_STRMU]
Streptococcus mutans, a facultatively aerobic and Gram-positive bacterium, is the primary causative agent of dental caries and contributes to the multispecies biofilm known as dental plaque. In this study, the aromatic-amino-acid aminotransferase from Streptococcus mutans (SmAroAT) was recombinantly expressed in Escherichia coli. An effective purification protocol was established. The recombinant protein was crystallized using the hanging-drop vapor-diffusion method with PEG 3350 as the primary precipitant. The crystal structure of SmAroAT was solved at 2.2 A resolution by the molecular-replacement method. Structural analysis indicated that the proteins of the aromatic-amino-acid aminotransferase family have conserved structural elements that might play a role in substrate binding. These results may help in obtaining a better understanding of the catabolism and biosynthesis of aromatic amino acids.
 
Crystal structure of the aromatic-amino-acid aminotransferase from Streptococcus mutans.,Cong X, Li X, Li S Acta Crystallogr F Struct Biol Commun. 2019 Feb 1;75(Pt 2):141-146. doi:, 10.1107/S2053230X18018472. Epub 2019 Jan 24. PMID:30713166<ref>PMID:30713166</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4my5" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Strmu]]
[[Category: Streptococcus mutans UA159]]
[[Category: Cong, X]]
[[Category: Cong X]]
[[Category: Feng, X]]
[[Category: Feng X]]
[[Category: Feng, Y]]
[[Category: Feng Y]]
[[Category: Ge, J]]
[[Category: Ge J]]
[[Category: Li, S]]
[[Category: Li S]]
[[Category: Li, X]]
[[Category: Li X]]
[[Category: Amino acid metabolism]]
[[Category: Oral infectious disease]]
[[Category: Smaroat]]
[[Category: Transferase]]
[[Category: Type 1 plp-dependent aminotransferase]]

Latest revision as of 11:56, 20 March 2024

Crystal structure of the aromatic amino acid aminotransferase from Streptococcus mutantsCrystal structure of the aromatic amino acid aminotransferase from Streptococcus mutants

Structural highlights

4my5 is a 4 chain structure with sequence from Streptococcus mutans UA159. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.194Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q8DWM1_STRMU

4my5, resolution 2.19Å

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OCA
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