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{{STRUCTURE_4iy4|  PDB=4iy4  |  SCENE=  }}
===Structural and ligand binding properties of the Bateman domain of human magnesium transporters CNNM2 and CNNM4===


==Disease==
==Structural and ligand binding properties of the Bateman domain of human magnesium transporters CNNM2 and CNNM4==
[[http://www.uniprot.org/uniprot/CNNM2_HUMAN CNNM2_HUMAN]] Familial primary hypomagnesemia with normocalcuria and normocalcemia. The disease is caused by mutations affecting the gene represented in this entry.  
<StructureSection load='4iy4' size='340' side='right'caption='[[4iy4]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[4iy4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IY4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IY4 FirstGlance]. <br>
[[http://www.uniprot.org/uniprot/CNNM2_HUMAN CNNM2_HUMAN]] Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity).  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iy4 OCA], [https://pdbe.org/4iy4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iy4 RCSB], [https://www.ebi.ac.uk/pdbsum/4iy4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iy4 ProSAT]</span></td></tr>
==About this Structure==
</table>
[[4iy4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IY4 OCA].
== Disease ==
[[Category: Accardi, A.]]
[https://www.uniprot.org/uniprot/CNNM2_HUMAN CNNM2_HUMAN] Familial primary hypomagnesemia with normocalcuria and normocalcemia. The disease is caused by mutations affecting the gene represented in this entry.
[[Category: Corral-Rodriguez, M A.]]
== Function ==
[[Category: Diercks, T.]]
[https://www.uniprot.org/uniprot/CNNM2_HUMAN CNNM2_HUMAN] Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity).
[[Category: Encinar, J A.]]
__TOC__
[[Category: Ereno-Orbea, J.]]
</StructureSection>
[[Category: Gomez-Garcia, I.]]
[[Category: Homo sapiens]]
[[Category: Martinez-Cruz, L A.]]
[[Category: Large Structures]]
[[Category: Muller, D.]]
[[Category: Accardi A]]
[[Category: Oyenarte, I.]]
[[Category: Corral-Rodriguez MA]]
[[Category: Spiwok, V.]]
[[Category: Diercks T]]
[[Category: Stuiver, M.]]
[[Category: Encinar JA]]
[[Category: Terashima, H.]]
[[Category: Ereno-Orbea J]]
[[Category: Bateman domain]]
[[Category: Gomez-Garcia I]]
[[Category: Cbs domain]]
[[Category: Martinez-Cruz LA]]
[[Category: Cytosol]]
[[Category: Muller D]]
[[Category: Magnesium sensor]]
[[Category: Oyenarte I]]
[[Category: Magnesium transport]]
[[Category: Spiwok V]]
[[Category: Metal transport]]
[[Category: Stuiver M]]
[[Category: Terashima H]]

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