4hyc: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4hyc]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanoculleus_marisnigri_JR1 Methanoculleus marisnigri JR1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HYC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HYC FirstGlance]. <br>
<table><tr><td colspan='2'>[[4hyc]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanoculleus_marisnigri_JR1 Methanoculleus marisnigri JR1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HYC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HYC FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hyc OCA], [https://pdbe.org/4hyc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hyc RCSB], [https://www.ebi.ac.uk/pdbsum/4hyc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hyc ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.95&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hyc OCA], [https://pdbe.org/4hyc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hyc RCSB], [https://www.ebi.ac.uk/pdbsum/4hyc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hyc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[https://www.uniprot.org/uniprot/A3CWV0_METMJ A3CWV0_METMJ]  
[https://www.uniprot.org/uniprot/A3CWV0_METMJ A3CWV0_METMJ]  
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Presenilin and signal peptide peptidase (SPP) are intramembrane aspartyl proteases that regulate important biological functions in eukaryotes. Mechanistic understanding of presenilin and SPP has been hampered by lack of relevant structural information. Here we report the crystal structure of a presenilin/SPP homologue (PSH) from the archaeon Methanoculleus marisnigri JR1. The protease, comprising nine transmembrane segments (TMs), adopts a previously unreported protein fold. The amino-terminal domain, consisting of TM1-6, forms a horseshoe-shaped structure, surrounding TM7-9 of the carboxy-terminal domain. The two catalytic aspartate residues are located on the cytoplasmic side of TM6 and TM7, spatially close to each other and approximately 8 A into the lipid membrane surface. Water molecules gain constant access to the catalytic aspartates through a large cavity between the amino- and carboxy-terminal domains. Structural analysis reveals insights into the presenilin/SPP family of intramembrane proteases.
Structure of a presenilin family intramembrane aspartate protease.,Li X, Dang S, Yan C, Gong X, Wang J, Shi Y Nature. 2012 Dec 19. doi: 10.1038/nature11801. PMID:23254940<ref>PMID:23254940</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4hyc" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>

Latest revision as of 11:52, 20 March 2024

Structure of a presenilin family intramembrane aspartate protease in P2 space groupStructure of a presenilin family intramembrane aspartate protease in P2 space group

Structural highlights

4hyc is a 8 chain structure with sequence from Methanoculleus marisnigri JR1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.95Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

A3CWV0_METMJ

4hyc, resolution 3.95Å

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