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[[Image:4hta.jpg|left|200px]]


{{STRUCTURE_4hta|  PDB=4hta  |  SCENE=  }}
==The structure of the karrikin insensitive (KAI2) protein in Arabidopsis thaliana==
 
<StructureSection load='4hta' size='340' side='right'caption='[[4hta]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
===The structure of the karrikin insensitive (KAI2) protein in Arabidopsis thaliana===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4hta]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HTA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HTA FirstGlance]. <br>
{{ABSTRACT_PUBMED_23349965}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.901&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hta FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hta OCA], [https://pdbe.org/4hta PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hta RCSB], [https://www.ebi.ac.uk/pdbsum/4hta PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hta ProSAT]</span></td></tr>
[[4hta]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HTA OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/KAI2_ARATH KAI2_ARATH] Involved in seed germination and seedling development. Essential for plant responses to karrikins, a class of butenolide compounds, structurally similar to strigolactones, released from burning vegetation that stimulate seed germination and enhance seedling photomorphogenesis. KAI2 is not required for strigolactone-mediated responses, but MAX2 is necessary for responses to karrikins and strigolactones.<ref>PMID:20864454</ref> <ref>PMID:22357928</ref> <ref>PMID:23142794</ref> <ref>PMID:23301669</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
[[Category: Bond, C S.]]
[[Category: Large Structures]]
[[Category: Bythell-Douglas, R.]]
[[Category: Bond CS]]
[[Category: Flematti, G R.]]
[[Category: Bythell-Douglas R]]
[[Category: Scaffidi, A.]]
[[Category: Flematti GR]]
[[Category: Smith, S M.]]
[[Category: Scaffidi A]]
[[Category: Waters, M T.]]
[[Category: Smith SM]]
[[Category: Alpha/beta hydrolase]]
[[Category: Waters MT]]
[[Category: Hydrolase]]
[[Category: Signaling protein]]

Latest revision as of 11:52, 20 March 2024

The structure of the karrikin insensitive (KAI2) protein in Arabidopsis thalianaThe structure of the karrikin insensitive (KAI2) protein in Arabidopsis thaliana

Structural highlights

4hta is a 1 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.901Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KAI2_ARATH Involved in seed germination and seedling development. Essential for plant responses to karrikins, a class of butenolide compounds, structurally similar to strigolactones, released from burning vegetation that stimulate seed germination and enhance seedling photomorphogenesis. KAI2 is not required for strigolactone-mediated responses, but MAX2 is necessary for responses to karrikins and strigolactones.[1] [2] [3] [4]

References

  1. ↑ Sun XD, Ni M. HYPOSENSITIVE TO LIGHT, an alpha/beta fold protein, acts downstream of ELONGATED HYPOCOTYL 5 to regulate seedling de-etiolation. Mol Plant. 2011 Jan;4(1):116-26. doi: 10.1093/mp/ssq055. Epub 2010 Sep 23. PMID:20864454 doi:10.1093/mp/ssq055
  2. ↑ Waters MT, Nelson DC, Scaffidi A, Flematti GR, Sun YK, Dixon KW, Smith SM. Specialisation within the DWARF14 protein family confers distinct responses to karrikins and strigolactones in Arabidopsis. Development. 2012 Apr;139(7):1285-95. doi: 10.1242/dev.074567. Epub 2012 Feb 22. PMID:22357928 doi:10.1242/dev.074567
  3. ↑ Waters MT, Smith SM. KAI2- and MAX2-mediated responses to karrikins and strigolactones are largely independent of HY5 in Arabidopsis seedlings. Mol Plant. 2013 Jan;6(1):63-75. doi: 10.1093/mp/sss127. Epub 2012 Nov 9. PMID:23142794 doi:10.1093/mp/sss127
  4. ↑ Kagiyama M, Hirano Y, Mori T, Kim SY, Kyozuka J, Seto Y, Yamaguchi S, Hakoshima T. Structures of D14 and D14L in the strigolactone and karrikin signaling pathways. Genes Cells. 2013 Jan 10. doi: 10.1111/gtc.12025. PMID:23301669 doi:10.1111/gtc.12025

4hta, resolution 1.90Å

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