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==Crystal Structure of mutant form of Caspase-7== | |||
<StructureSection load='4hq0' size='340' side='right'caption='[[4hq0]], [[Resolution|resolution]] 3.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4hq0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HQ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HQ0 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hq0 OCA], [https://pdbe.org/4hq0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hq0 RCSB], [https://www.ebi.ac.uk/pdbsum/4hq0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hq0 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death. | |||
==See Also== | |||
*[[Caspase 3D structures|Caspase 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Bae K-H]] | |||
[[Category: Chung SJ]] | |||
[[Category: Kang HJ]] | |||
[[Category: Kim SJ]] | |||
[[Category: Lee Y]] | |||
Latest revision as of 11:52, 20 March 2024
Crystal Structure of mutant form of Caspase-7Crystal Structure of mutant form of Caspase-7
Structural highlights
FunctionCASP7_HUMAN Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death. See Also |
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