3wz2: Difference between revisions

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 ==Crystal structure of Pyrococcus furiosus PbaA, an archaeal homolog of proteasome-assembly chaperone==
-<StructureSection load='3wz2' size='340' side='right' caption='[[3wz2]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
+<StructureSection load='3wz2' size='340' side='right'caption='[[3wz2]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3wz2]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WZ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WZ2 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3wz2]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus_DSM_3638 Pyrococcus furiosus DSM 3638]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WZ2 FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3vr0|3vr0]], [[3gaa|3gaa]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wz2 OCA], [http://pdbe.org/3wz2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wz2 RCSB], [http://www.ebi.ac.uk/pdbsum/3wz2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wz2 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wz2 OCA], [https://pdbe.org/3wz2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wz2 RCSB], [https://www.ebi.ac.uk/pdbsum/3wz2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wz2 ProSAT]</span></td></tr>
 </table>
-<div style="background-color:#fffaf0;">
+== Function ==
-== Publication Abstract from PubMed ==
+[https://www.uniprot.org/uniprot/Q8U4Q9_PYRFU Q8U4Q9_PYRFU]
-Formation of the eukaryotic proteasome is not a spontaneous process but a highly ordered process assisted by several assembly chaperones. In contrast, archaeal proteasome subunits can spontaneously assemble into an active form. Recent bioinformatic analysis identified the proteasome-assembly chaperone-like proteins, PbaA and PbaB, in archaea. Our previous study showed that the PbaB homotetramer functions as a proteasome activator through its tentacle-like C-terminal segments. However, a functional role of the other homolog PbaA has remained elusive. Here we determined the 2.25-A resolution structure of PbaA, illustrating its disparate tertiary and quaternary structures compared with PbaB. PbaA forms a homopentamer in which the C-terminal segments, with a putative proteasome-activating motif, are packed against the core. These findings offer deeper insights into the molecular evolution relationships between the proteasome-assembly chaperones and the proteasome activators.
-Crystal structure of archaeal homolog of proteasome-assembly chaperone PbaA.,Sikdar A, Satoh T, Kawasaki M, Kato K Biochem Biophys Res Commun. 2014 Oct 5. pii: S0006-291X(14)01751-3. doi:, 10.1016/j.bbrc.2014.09.114. PMID:25285636<ref>PMID:25285636</ref>
-From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-</div>
-<div class="pdbe-citations 3wz2" style="background-color:#fffaf0;"></div>
-== References ==
-<references/>
 __TOC__
 </StructureSection>
-[[Category: Kato, K]]
+[[Category: Large Structures]]
-[[Category: Kawasaki, M]]
+[[Category: Pyrococcus furiosus DSM 3638]]
-[[Category: Satoh, T]]
+[[Category: Kato K]]
-[[Category: Sikdar, A]]
+[[Category: Kawasaki M]]
-[[Category: Chaperone]]
+[[Category: Satoh T]]
-[[Category: Proteasome]]
+[[Category: Sikdar A]]
-[[Category: Proteasome activator]]
-[[Category: Proteasome assembly chaperone]]