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{{STRUCTURE_3vwe|  PDB=3vwe  |  SCENE=  }}
===Crystal structure of alpha-tubulin acetyltransferase domain of human Mec-17 in complex with CoA (P21 form)===


==Function==
==Crystal structure of alpha-tubulin acetyltransferase domain of human Mec-17 in complex with CoA (P21 form)==
[[http://www.uniprot.org/uniprot/ATAT_HUMAN ATAT_HUMAN]] Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. May affect microtubule stability and regulate microtubule dynamics. May be involved in neuron development.<ref>PMID:20829795</ref>
<StructureSection load='3vwe' size='340' side='right'caption='[[3vwe]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3vwe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VWE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VWE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.956&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vwe OCA], [https://pdbe.org/3vwe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vwe RCSB], [https://www.ebi.ac.uk/pdbsum/3vwe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vwe ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ATAT_HUMAN ATAT_HUMAN] Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. May affect microtubule stability and regulate microtubule dynamics. May be involved in neuron development.<ref>PMID:20829795</ref>  


==About this Structure==
==See Also==
[[3vwe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VWE OCA].
*[[Alpha-tubulin N-acetyltransferase|Alpha-tubulin N-acetyltransferase]]
 
*[[Alpha-tubulin N-acetyltransferase 3D structures|Alpha-tubulin N-acetyltransferase 3D structures]]
==Reference==
*[[Tubulin acetyltransferase|Tubulin acetyltransferase]]
<references group="xtra"/><references/>
== References ==
[[Category: Alpha-tubulin N-acetyltransferase]]
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Sumimoto, H.]]
[[Category: Large Structures]]
[[Category: Yuzawa, S.]]
[[Category: Sumimoto H]]
[[Category: Acetyltransferase]]
[[Category: Yuzawa S]]
[[Category: Gnat fold]]
[[Category: Transferase]]

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