3vne: Difference between revisions

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==Structure of the ebolavirus protein VP24 from Sudan==
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<StructureSection load='3vne' size='340' side='right'caption='[[3vne]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3vne]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sudan_ebolavirus Sudan ebolavirus]. The October 2014 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Ebola Virus Proteins''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2014_10 10.2210/rcsb_pdb/mom_2014_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VNE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VNE FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vne OCA], [https://pdbe.org/3vne PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vne RCSB], [https://www.ebi.ac.uk/pdbsum/3vne PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vne ProSAT]</span></td></tr>
{{STRUCTURE_3vne|  PDB=3vne  |  SCENE=  }}
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== Function ==
[https://www.uniprot.org/uniprot/VP24_EBOSU VP24_EBOSU] Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1, by interacting with the STAT1-binding region of host importin alpha-1/KPNA1 protein, thereby inhibiting the latter. Without the activity of this protein, activated STAT1 would not enter the nucleus and be unable to activate IFN-induced genes. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.


===Structure of the ebolavirus protein VP24 from Sudan===
==See Also==
 
*[[VP24|VP24]]
 
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[[Category: Ebola Virus Proteins]]
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[[Category: Large Structures]]
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[[Category: RCSB PDB Molecule of the Month]]
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==About this Structure==
[[3vne]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sudan_ebolavirus Sudan ebolavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VNE OCA].
 
==Reference==
<ref group="xtra">PMID:022383882</ref><references group="xtra"/>
[[Category: Sudan ebolavirus]]
[[Category: Sudan ebolavirus]]
[[Category: Zhang, A P.P.]]
[[Category: Zhang APP]]
[[Category: Ebolavirus]]
[[Category: Ifn response pathway]]
[[Category: Interferon antagonist]]
[[Category: Karyopherin alpha]]
[[Category: Reston]]
[[Category: Stat1]]
[[Category: Sudan]]
[[Category: Viral protein]]
[[Category: Vp24]]
[[Category: Vp35]]
[[Category: Zaire]]

Latest revision as of 11:40, 20 March 2024

Structure of the ebolavirus protein VP24 from SudanStructure of the ebolavirus protein VP24 from Sudan

Structural highlights

3vne is a 1 chain structure with sequence from Sudan ebolavirus. The October 2014 RCSB PDB Molecule of the Month feature on Ebola Virus Proteins by David Goodsell is 10.2210/rcsb_pdb/mom_2014_10. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

VP24_EBOSU Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1, by interacting with the STAT1-binding region of host importin alpha-1/KPNA1 protein, thereby inhibiting the latter. Without the activity of this protein, activated STAT1 would not enter the nucleus and be unable to activate IFN-induced genes. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.

See Also

3vne, resolution 2.00Å

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