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==Crystal Structure of the Periplasmic Catecholate-Siderophore Binding Protein VctP from Vibrio Cholerae==
==Crystal Structure of the Periplasmic Catecholate-Siderophore Binding Protein VctP from Vibrio Cholerae==
<StructureSection load='3tef' size='340' side='right' caption='[[3tef]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='3tef' size='340' side='right'caption='[[3tef]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3tef]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TEF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TEF FirstGlance]. <br>
<table><tr><td colspan='2'>[[3tef]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TEF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TEF FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VC_A0227 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=666 Vibrio cholerae])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.698&#8491;</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tef OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tef RCSB], [http://www.ebi.ac.uk/pdbsum/3tef PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tef OCA], [https://pdbe.org/3tef PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tef RCSB], [https://www.ebi.ac.uk/pdbsum/3tef PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tef ProSAT]</span></td></tr>
<table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/Q9KMU2_VIBCH Q9KMU2_VIBCH]
VctP, one of the two essential siderophore-binding PBPs from the pathogen Vibrio cholerae, plays an important role in the transport of enterobactin and vibriobactin, which have quite different configurations of iron coordination, from the periplasm to the inner membrane. The current study reports the crystal structure of VctP from V. cholerae N16961 at 1.7A resolution. A structural comparison of VctP with its homologues and the results of molecular docking indicate that enterobactin and vibriobactin share the same binding pocket. Significantly, a basic triad consisting of Arg137, Arg226 and Arg270 is used to balance the three negative charges of ferric-enterobactin, while a basic dyad consisting of Arg137 and Arg270 is used to balance the two negative charges of ferric-vibriobactin.
 
Crystal structure of periplasmic catecholate-siderophore binding protein VctP from Vibrio cholerae at 1.7 A resolution.,Liu X, Du Q, Wang Z, Liu S, Li N, Chen Y, Zhu C, Zhu D, Wei T, Huang Y, Xu S, Gu L FEBS Lett. 2012 Apr 24;586(8):1240-4. Epub 2012 Mar 28. PMID:22575663<ref>PMID:22575663</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Vibrio cholerae]]
[[Category: Vibrio cholerae]]
[[Category: Chen, Y.]]
[[Category: Chen Y]]
[[Category: Gu, L.]]
[[Category: Gu L]]
[[Category: Huang, Y.]]
[[Category: Huang Y]]
[[Category: Li, N.]]
[[Category: Li N]]
[[Category: Liu, S.]]
[[Category: Liu S]]
[[Category: Liu, X.]]
[[Category: Liu X]]
[[Category: Wang, Z.]]
[[Category: Wang Z]]
[[Category: Wei, T.]]
[[Category: Wei T]]
[[Category: Xu, S.]]
[[Category: Xu S]]
[[Category: Zhu, C.]]
[[Category: Zhu C]]
[[Category: Zhu, D.]]
[[Category: Zhu D]]
[[Category: Siderophore-binding protein]]
[[Category: Transport protein]]

Latest revision as of 11:37, 20 March 2024

Crystal Structure of the Periplasmic Catecholate-Siderophore Binding Protein VctP from Vibrio CholeraeCrystal Structure of the Periplasmic Catecholate-Siderophore Binding Protein VctP from Vibrio Cholerae

Structural highlights

3tef is a 1 chain structure with sequence from Vibrio cholerae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.698Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q9KMU2_VIBCH

3tef, resolution 1.70Å

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OCA
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