3s68: Difference between revisions

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[[Image:3s68.png|left|200px]]


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==Rat COMT in complex with SAM and Tolcapone at 1.85A, P3221, Rfree=22.0==
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<StructureSection load='3s68' size='340' side='right'caption='[[3s68]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3s68]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S68 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TCW:TOLCAPONE'>TCW</scene></td></tr>
{{STRUCTURE_3s68|  PDB=3s68  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s68 OCA], [https://pdbe.org/3s68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s68 RCSB], [https://www.ebi.ac.uk/pdbsum/3s68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s68 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/COMT_RAT COMT_RAT] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.


===Rat COMT in complex with SAM and Tolcapone at 1.85A, P3221, Rfree=22.0===
==See Also==
 
*[[Catechol O-methyltransferase 3D structures|Catechol O-methyltransferase 3D structures]]
 
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_22349227}}
 
==About this Structure==
[[3s68]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S68 OCA].
 
==Reference==
<ref group="xtra">PMID:022349227</ref><references group="xtra"/>
[[Category: Catechol O-methyltransferase]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Rudolph, M G.]]
[[Category: Benz J]]
[[Category: Methyltransferase]]
[[Category: Ehler A]]
[[Category: Neurotransmitter degradation]]
[[Category: Rudolph MG]]
[[Category: Transferase-transferase inhibitor complex]]
[[Category: Schlatter D]]
[[Category: Stihle M]]

Latest revision as of 11:36, 20 March 2024

Rat COMT in complex with SAM and Tolcapone at 1.85A, P3221, Rfree=22.0Rat COMT in complex with SAM and Tolcapone at 1.85A, P3221, Rfree=22.0

Structural highlights

3s68 is a 1 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.85Å
Ligands:, , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

COMT_RAT Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.

See Also

3s68, resolution 1.85Å

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