3s5a: Difference between revisions

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-'''Unreleased structure'''
-The entry 3s5a is ON HOLD  until Paper Publication
+==ABH2 cross-linked to undamaged dsDNA-2 with cofactors==
+<StructureSection load='3s5a' size='340' side='right'caption='[[3s5a]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3s5a]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S5A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S5A FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=XL3:PROPANE-1-THIOL'>XL3</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s5a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s5a OCA], [https://pdbe.org/3s5a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s5a RCSB], [https://www.ebi.ac.uk/pdbsum/3s5a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s5a ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ALKB2_HUMAN ALKB2_HUMAN] Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.<ref>PMID:12486230</ref> <ref>PMID:12594517</ref> <ref>PMID:16174769</ref> <ref>PMID:18519673</ref> <ref>PMID:18432238</ref>
-Authors: Yi, C., Chen, B., Qi, B., Ramirez, B., Zhang, W., Jia, G., Zhang, L., Li, C.Q., Dinner, A.R., Yang, C.-G., He, C.
+==See Also==
+*[[Dioxygenase 3D structures|Dioxygenase 3D structures]]
-Description: ABH2 cross-linked to undamaged dsDNA-2 with cofactors
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Chen B]]
+[[Category: Dinner AR]]
+[[Category: He C]]
+[[Category: Jia G]]
+[[Category: Li CQ]]
+[[Category: Qi B]]
+[[Category: Ramirez B]]
+[[Category: Yang C-G]]
+[[Category: Yi C]]
+[[Category: Zhang L]]
+[[Category: Zhang W]]