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==Structure of a M. tuberculosis Salicylate Synthase, MbtI, in Complex with an Inhibitor with Isopropyl R-Group== | |||
<StructureSection load='3rv7' size='340' side='right'caption='[[3rv7]], [[Resolution|resolution]] 2.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3rv7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RV7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RV7 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RVB:3-{[(1Z)-1-CARBOXY-3-METHYLBUT-1-EN-1-YL]OXY}-2-HYDROXYBENZOIC+ACID'>RVB</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rv7 OCA], [https://pdbe.org/3rv7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rv7 RCSB], [https://www.ebi.ac.uk/pdbsum/3rv7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rv7 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/MBTI_MYCTU MBTI_MYCTU] Mediates the production of salicylate from chorismate via an isochorismate intermediate. Presents both isochorismate synthase and isochorismate-pyruvate lyase activities. Salycilate is the starter unit in the production of the virulence-conferring salicylate-based siderophore mycobactin.<ref>PMID:16923875</ref> | |||
==See Also== | |||
*[[Isochorismate pyruvate lyase|Isochorismate pyruvate lyase]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mycobacterium tuberculosis]] | |||
[[Category: Bulloch EMM]] | |||
[[Category: Chi G]] | |||
[[Category: Lott JS]] | |||
[[Category: Manos-Turvey A]] | |||
[[Category: Payne RJ]] | |||
Latest revision as of 11:36, 20 March 2024
Structure of a M. tuberculosis Salicylate Synthase, MbtI, in Complex with an Inhibitor with Isopropyl R-GroupStructure of a M. tuberculosis Salicylate Synthase, MbtI, in Complex with an Inhibitor with Isopropyl R-Group
Structural highlights
FunctionMBTI_MYCTU Mediates the production of salicylate from chorismate via an isochorismate intermediate. Presents both isochorismate synthase and isochorismate-pyruvate lyase activities. Salycilate is the starter unit in the production of the virulence-conferring salicylate-based siderophore mycobactin.[1] See AlsoReferences
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