3rv8: Difference between revisions

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-'''Unreleased structure'''
-The entry 3rv8 is ON HOLD
+==Structure of a M. tuberculosis Salicylate Synthase, MbtI, in Complex with an Inhibitor with Cyclopropyl R-Group==
+<StructureSection load='3rv8' size='340' side='right'caption='[[3rv8]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3rv8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RV8 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.29&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RVC:3-{[(Z)-1-CARBOXY-2-CYCLOPROPYLETHENYL]OXY}-2-HYDROXYBENZOIC+ACID'>RVC</scene>, <scene name='pdbligand=VCE:3-{[(E)-1-CARBOXY-2-CYCLOPROPYLETHENYL]OXY}-2-HYDROXYBENZOIC+ACID'>VCE</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rv8 OCA], [https://pdbe.org/3rv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rv8 RCSB], [https://www.ebi.ac.uk/pdbsum/3rv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rv8 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/MBTI_MYCTU MBTI_MYCTU] Mediates the production of salicylate from chorismate via an isochorismate intermediate. Presents both isochorismate synthase and isochorismate-pyruvate lyase activities. Salycilate is the starter unit in the production of the virulence-conferring salicylate-based siderophore mycobactin.<ref>PMID:16923875</ref>
-Authors: Chi, G., Bulloch, E. M. M., Manos-Turvey, A., Payne, R. J., Lott, J. S., TB Structural Genomics Consortium (TBSGC)
+==See Also==
+*[[Isochorismate pyruvate lyase|Isochorismate pyruvate lyase]]
-Description: Structure of a M. tuberculosis Salicylate Synthase, MbtI, in Complex with an Inhibitor with Cyclopropyl R-Group
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Mycobacterium tuberculosis]]
+[[Category: Bulloch EMM]]
+[[Category: Chi G]]
+[[Category: Lott JS]]
+[[Category: Manos-Turvey A]]
+[[Category: Payne RJ]]