3rg9: Difference between revisions

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[[Image:3rg9.png|left|200px]]


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==Trypanosoma brucei dihydrofolate reductase (TbDHFR) in complex with WR99210==
The line below this paragraph, containing "STRUCTURE_3rg9", creates the "Structure Box" on the page.
<StructureSection load='3rg9' size='340' side='right'caption='[[3rg9]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3rg9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_rhodesiense Trypanosoma brucei rhodesiense]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RG9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RG9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=WRA:6,6-DIMETHYL-1-[3-(2,4,5-TRICHLOROPHENOXY)PROPOXY]-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE'>WRA</scene></td></tr>
{{STRUCTURE_3rg9|  PDB=3rg9  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rg9 OCA], [https://pdbe.org/3rg9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rg9 RCSB], [https://www.ebi.ac.uk/pdbsum/3rg9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rg9 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DRTS_TRYBB DRTS_TRYBB] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity).


===Trypanosoma brucei dihydrofolate reductase (TbDHFR) in complex with WR99210===
==See Also==
 
*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
 
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[[Category: Large Structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 21650210 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21650210}}
 
==About this Structure==
[[3rg9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei_rhodesiense Trypanosoma brucei rhodesiense]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RG9 OCA].
 
==Reference==
<ref group="xtra">PMID:021650210</ref><references group="xtra"/>
[[Category: Dihydrofolate reductase]]
[[Category: Trypanosoma brucei rhodesiense]]
[[Category: Trypanosoma brucei rhodesiense]]
[[Category: Vanichtanankul, J.]]
[[Category: Vanichtanankul J]]
[[Category: Yuthavong, Y.]]
[[Category: Yuthavong Y]]
[[Category: Yuvaniyama, J.]]
[[Category: Yuvaniyama J]]
[[Category: Dihydrofolate reductase]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
[[Category: Trypanosoma brucei]]
[[Category: Wr99210]]

Latest revision as of 11:35, 20 March 2024

Trypanosoma brucei dihydrofolate reductase (TbDHFR) in complex with WR99210Trypanosoma brucei dihydrofolate reductase (TbDHFR) in complex with WR99210

Structural highlights

3rg9 is a 2 chain structure with sequence from Trypanosoma brucei rhodesiense. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DRTS_TRYBB Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity).

See Also

3rg9, resolution 2.00Å

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OCA
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