3l9h: Difference between revisions

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-{{Seed}}
-[[Image:3l9h.jpg|left|200px]]
-<!--
+==X-ray structure of mitotic kinesin-5 (KSP, KIF11, Eg5)in complex with the hexahydro-2H-pyrano[3,2-c]quinoline EMD 534085==
-The line below this paragraph, containing "STRUCTURE_3l9h", creates the "Structure Box" on the page.
+<StructureSection load='3l9h' size='340' side='right'caption='[[3l9h]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3l9h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L9H FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=EMQ:1-[2-(DIMETHYLAMINO)ETHYL]-3-{[(2R,4AS,5R,10BS)-5-PHENYL-9-(TRIFLUOROMETHYL)-3,4,4A,5,6,10B-HEXAHYDRO-2H-PYRANO[3,2-C]QUINOLIN-2-YL]METHYL}UREA'>EMQ</scene></td></tr>
-{{STRUCTURE_3l9h|  PDB=3l9h  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l9h OCA], [https://pdbe.org/3l9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l9h RCSB], [https://www.ebi.ac.uk/pdbsum/3l9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l9h ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN] Defects in KIF11 are the cause of microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR) [MIM:[https://omim.org/entry/152950 152950]. An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes.<ref>PMID:22284827</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN] Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.<ref>PMID:19001501</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l9/3l9h_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3l9h ConSurf].
+<div style="clear:both"></div>
-===X-ray structure of mitotic kinesin-5 (KSP, KIF11, Eg5)in complex with the hexahydro-2H-pyrano[3,2-c]quinoline EMD 534085===
+==See Also==
+*[[Kinesin 3D Structures|Kinesin 3D Structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_20149654}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 20149654 is the PubMed ID number.
+</StructureSection>
--->
-{{ABSTRACT_PUBMED_20149654}}
-==About this Structure==
-L9H is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L9H OCA].
-==Reference==
-<ref group="xtra">PMID:20149654</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Knoechel, T.]]
+[[Category: Large Structures]]
-[[Category: Acetylation]]
+[[Category: Knoechel T]]
-[[Category: Atp-binding]]
-[[Category: Cell cycle]]
-[[Category: Cell division]]
-[[Category: Coiled coil]]
-[[Category: Eg5]]
-[[Category: Emd 534085]]
-[[Category: Microtubule]]
-[[Category: Mitosis]]
-[[Category: Mitotic spindle kinesin]]
-[[Category: Motor protein]]
-[[Category: Nucleotide-binding]]
-[[Category: Phosphoprotein]]
-[[Category: Polymorphism]]
-[[Category: Small molecule inhibitor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar  3 16:19:51 2010''