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{{STRUCTURE_3km5|  PDB=3km5  |  SCENE=  }}
===Crystal Structure Analysis of the K2 Cleaved Adhesin Domain of Lys-gingipain (Kgp)===
{{ABSTRACT_PUBMED_20233299}}


==Function==
==Crystal Structure Analysis of the K2 Cleaved Adhesin Domain of Lys-gingipain (Kgp)==
[[http://www.uniprot.org/uniprot/O52050_PORGI O52050_PORGI]] Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the functions of polymorphonuclear leukocytes. May act as a virulence factor in the development of peridontal disease. Involved in the coaggregation of P.gingivalis with other oral bacteria (By similarity).[UniProtKB:B2RLK2]  
<StructureSection load='3km5' size='340' side='right'caption='[[3km5]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[3km5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Porphyromonas_gingivalis_W83 Porphyromonas gingivalis W83]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KM5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KM5 FirstGlance]. <br>
[[3km5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Porphyromonas_gingivalis Porphyromonas gingivalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KM5 OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3km5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3km5 OCA], [https://pdbe.org/3km5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3km5 RCSB], [https://www.ebi.ac.uk/pdbsum/3km5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3km5 ProSAT]</span></td></tr>
<ref group="xtra">PMID:020233299</ref><references group="xtra"/><references/>
</table>
[[Category: Porphyromonas gingivalis]]
== Function ==
[[Category: Collyer, C A.]]
[https://www.uniprot.org/uniprot/HAGA1_PORGI HAGA1_PORGI] Agglutinates erythrocytes.
[[Category: Hunter, N.]]
== Evolutionary Conservation ==
[[Category: Li, N.]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: Beta jelly roll barrel]]
Check<jmol>
[[Category: Cell invasion]]
  <jmolCheckbox>
[[Category: Cleaved adhesin family]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/km/3km5_consurf.spt"</scriptWhenChecked>
[[Category: Hemagglutination domain]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Lys-gingipain]]
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3km5 ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Porphyromonas gingivalis W83]]
[[Category: Collyer CA]]
[[Category: Hunter N]]
[[Category: Li N]]

Latest revision as of 11:29, 20 March 2024

Crystal Structure Analysis of the K2 Cleaved Adhesin Domain of Lys-gingipain (Kgp)Crystal Structure Analysis of the K2 Cleaved Adhesin Domain of Lys-gingipain (Kgp)

Structural highlights

3km5 is a 2 chain structure with sequence from Porphyromonas gingivalis W83. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.4Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

HAGA1_PORGI Agglutinates erythrocytes.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

3km5, resolution 1.40Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
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